Transcriptome and regulatory maps of decidua-derived stromal cells inform gene discovery in preterm birth

Author:

Sakabe Noboru J.1ORCID,Aneas Ivy1ORCID,Knoblauch Nicholas1ORCID,Sobreira Debora R.1ORCID,Clark Nicole2,Paz Cristina1ORCID,Horth Cynthia1,Ziffra Ryan1,Kaur Harjot1,Liu Xiao1,Anderson Rebecca1,Morrison Jean1ORCID,Cheung Virginia C.3,Grotegut Chad4ORCID,Reddy Timothy E.5ORCID,Jacobsson Bo67ORCID,Hallman Mikko8ORCID,Teramo Kari9ORCID,Murtha Amy10ORCID,Kessler John3ORCID,Grobman William11,Zhang Ge12,Muglia Louis J.13ORCID,Rana Sarosh13,Lynch Vincent J.1ORCID,Crawford Gregory E.2ORCID,Ober Carole113,He Xin1ORCID,Nóbrega Marcelo A.1ORCID

Affiliation:

1. Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA.

2. Department of Pediatrics, Center for Genomic and Computational Biology, Duke University, Durham, NC 27705, USA.

3. Department of Neurology and Institute for Stem Cell Medicine, Northwestern University, Chicago, IL 60611, USA.

4. Department of Obstetrics and Gynecology, Duke University Health System, Durham, NC 27713, USA.

5. Department of Biostatistics and Bioinformatics, Center for Genomic and Computational Biology, Duke University, Durham, NC 27708, USA.

6. Department of Obstetrics and Gynecology, University of Gothenberg, Gothenberg, Sweden.

7. Department of Genetics and Bioinformatics, Area of Health Data and Digitalization, Institute of Public Health, Oslo, Norway.

8. Department of Children and Adolescents, Oulu University Hospital, Oulu, Finland.

9. Department of Obstetrics and Gynecology, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland.

10. Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Duke University School of Medicine, Durham, NC 27713, USA.

11. Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

12. Division of Human Genetics, Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA.

13. Department of Obstetrics and Gynecology, University of Chicago, Chicago IL 60637, USA.

Abstract

Functional annotations of a placental cell genome aid in identifying genes associated with preterm birth.

Funder

March of Dimes Foundation

March of Dimes Prematurity Research Center Ohio Collaborative

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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