Single-cell architecture and functional requirement of alternative splicing during hematopoietic stem cell formation

Author:

Wang Fang12ORCID,Tan Puwen3ORCID,Zhang Pengcheng45,Ren Yue12,Zhou Jie4,Li Yunqiao4,Hou Siyuan67ORCID,Li Shuaili4,Zhang Linlin4,Ma Yanni12,Wang Chaojie6,Tang Wanbo4,Wang Xiaoshuang12,Huo Yue12,Hu Yongfei3ORCID,Cui Tianyu3,Niu Chao5,Wang Dong3,Liu Bing4,Lan Yu6ORCID,Yu Jia12ORCID

Affiliation:

1. State Key Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing 100005, China.

2. The Key Laboratory of RNA and Hematopoietic Regulation, Chinese Academy of Medical Sciences, Beijing 100005, China.

3. Department of Bioinformatics, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China.

4. State Key Laboratory of Experimental Hematology, Fifth Medical Center of Chinese PLA General Hospital, Beijing 100071, China.

5. Department of Environmental Medicine, Tianjin Institute of Environmental and Operational Medicine, Tianjin 300050, China.

6. Key Laboratory for Regenerative Medicine of Ministry of Education, Institute of Hematology, School of Medicine, Jinan University, Guangzhou 510632, China.

7. Integrated Chinese and Western Medicine Postdoctoral Research Station, Jinan University, Guangzhou 510632, China.

Abstract

AS program is essential for HSC formation.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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