Vitamin D deficiency exacerbates UV/endorphin and opioid addiction

Author:

Kemény Lajos V.1ORCID,Robinson Kathleen C.1ORCID,Hermann Andrea L.1ORCID,Walker Deena M.2ORCID,Regan Susan3,Yew Yik Weng4ORCID,Lai Yi Chun5ORCID,Theodosakis Nicholas1ORCID,Rivera Phillip D.678ORCID,Ding Weihua9,Yang Liuyue9,Beyer Tobias1,Loh Yong-Hwee E.210ORCID,Lo Jennifer A.1ORCID,van der Sande Anita A. J.1,Sarnie William1,Kotler David1,Hsiao Jennifer J.1,Su Mack Y.1,Kato Shinichiro1,Kotler Joseph1,Bilbo Staci D.67,Chopra Vanita11,Salomon Matthew P.12,Shen Shiqian9ORCID,Hoon Dave S. B.12ORCID,Asgari Maryam M.13ORCID,Wakeman Sarah E.3ORCID,Nestler Eric J.2ORCID,Fisher David E.1ORCID

Affiliation:

1. Cutaneous Biology Research Center, Department of Dermatology and Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

2. Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

3. Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

4. National Skin Centre, Singapore, Singapore.

5. Rutgers New Jersey Medical School, Newark, NJ, USA.

6. Program in Neuroscience, Harvard Medical School, Boston, MA, USA.

7. Department of Pediatrics, Lurie Center for Autism, Massachusetts General Hospital for Children, Boston, MA, USA.

8. Department of Biology, Hope College, Holland, MI, USA.

9. MGH Center for Translational Pain Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

10. USC Libraries Bioinformatics Services, University of Southern California, Los Angeles, CA, USA.

11. Department of Neurology, Harvard Medical School, Massachusetts General Hospital, Charlestown, MA, USA.

12. Department of Translational Molecular Medicine, Division of Molecular Oncology, John Wayne Cancer Institute at Providence Saint John’s Health Center, Santa Monica, CA, USA.

13. Department of Dermatology, Massachusetts General Hospital and Department of Population Medicine, Harvard Medical School, Boston, MA, USA.

Abstract

Addiction to UV light and opioids is increased by VitD deficiency, suggesting that a feedback loop promotes its synthesis.

Funder

National Institutes of Health

National Institute of Arthritis and Musculoskeletal and Skin Diseases

ASCRS Research Foundation

Dr. Miriam and Sheldon G. Adelson Medical Research Foundation

Royal Perth Hospital Medical Research Foundation

Magyarország Kormánya

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference47 articles.

1. Key Substance Use and Mental Health Indicators in the United States: Results from the 2018 National Survey on Drug Use and Health | SAMHSA Publications (2019); https://store.samhsa.gov/product/Key-Substance-Use-and-Mental-Health-Indicators-in-the-United-States-Results-from-the-2018-National-Survey-on-Drug-Use-and-Health/PEP19-5068.

2. Opioid Crisis: No Easy Fix to Its Social and Economic Determinants

3. The Role of Science in Addressing the Opioid Crisis

4. Ultraviolet exposure is a reinforcing stimulus in frequent indoor tanners

5. Do adolescent indoor tanners exhibit dependency?

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