Adaptation to mitochondrial stress requires CHOP-directed tuning of ISR-Reference-Cited by-同舟云学术

Adaptation to mitochondrial stress requires CHOP-directed tuning of ISR

Published:2021-05-28 Issue:22 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Kaspar Sophie¹²^ORCID,Oertlin Christian³,Szczepanowska Karolina¹²^ORCID,Kukat Alexandra¹²^ORCID,Senft Katharina¹²^ORCID,Lucas Christina¹^ORCID,Brodesser Susanne¹^ORCID,Hatzoglou Maria⁴^ORCID,Larsson Ola³^ORCID,Topisirovic Ivan⁵^ORCID,Trifunovic Aleksandra¹²^ORCID

Affiliation:

1. Cologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases (CECAD), Medical Faculty, University of Cologne, D-50931 Cologne, Germany.

2. Institute for Mitochondrial Diseases and Ageing, Medical Faculty and Center for Molecular Medicine Cologne (CMMC) , University of Cologne, D-50931 Cologne, Germany.

3. Department of Oncology-Pathology, Science for Life Laboratory, Karolinska Institute, Stockholm, Sweden.

4. Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH 44106, USA.

5. Lady Davis Institute, SMBD Jewish General Hospital, Gerald Bronfman Department of Oncology and Departments of Experimental Medicine and Biochemistry, McGill University, Montreal, Canada.

Abstract

Upon mitochondrial dysfunction, CHOP acts as a rheostat that attenuates prolonged stress and delays the onset of cardiomyopathy.

Funder

National Institutes of Health

Deutsche Forschungsgemeinschaft

Cancerfonden

Vetenskapsrådet

Marianne and Marcus Wallenberg Foundation

Canadian Institutes for Health Research

Joint Canada-Israel Health Research Program

Publisher

American Association for the Advancement of Science (AAAS)