Label-free imaging of amyloid plaques in Alzheimer’s disease with stimulated Raman scattering microscopy-Reference-Cited by-同舟云学术

Label-free imaging of amyloid plaques in Alzheimer’s disease with stimulated Raman scattering microscopy

Published:2018-11-02 Issue:11 Volume:4 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Ji Minbiao¹²^ORCID,Arbel Michal³,Zhang Lili¹,Freudiger Christian W.⁴,Hou Steven S.³,Lin Dongdong¹^ORCID,Yang Xinju¹,Bacskai Brian J.³,Xie X. Sunney²

Affiliation:

1. State Key Laboratory of Surface Physics and Department of Physics, Multiscale Research Institute of Complex Systems, Human Phenome Institute, Key Laboratory of Micro and Nano Photonics Structures (Ministry of Education), Fudan University, Shanghai 200433, China.

2. Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.

3. Alzheimer’s Disease Research Laboratory, Department of Neurology, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.

4. Invenio Imaging Inc., Santa Clara, CA 95051, USA.

Abstract

Misfolded proteins in amyloid plaques in transgenic Alzheimer’s disease mouse brains are visualized directly without labeling.

Funder

National Institutes of Health

National Natural Science Foundation of China

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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3. Alzheimer's Disease: Genes, Proteins, and Therapy

4. The Amyloid State of Proteins in Human Diseases

5. Protein Misfolding, Functional Amyloid, and Human Disease

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