Structure of Drosophila melanogaster ARC1 reveals a repurposed molecule with characteristics of retroviral Gag-Reference-Cited by-同舟云学术

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Structure of Drosophila melanogaster ARC1 reveals a repurposed molecule with characteristics of retroviral Gag

Published:2020-01-03 Issue:1 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Cottee Matthew A.¹^ORCID,Letham Suzanne C.¹^ORCID,Young George R.²^ORCID,Stoye Jonathan P.²³^ORCID,Taylor Ian A.¹^ORCID

Affiliation:

1. Macromolecular Structure Laboratory, The Francis Crick Institute, Midland Road, London NW1 1AT, UK.

2. Retrovirus-Host Interactions Laboratory, The Francis Crick Institute, Midland Road, London NW1 1AT, UK.

3. Department of Medicine, Imperial College London, London SW7 2AZ, UK.

Abstract

Structural studies of dARC reveal a Gag exapted from a transposable element and an ancient relationship to orthoretroviruses.

Funder

Wellcome

Francis Crick Institute

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference60 articles.

1. Dynamics of bidirectional transport ofArc mRNA in neuronal dendrites

2. Arc/Arg3.1 Is Essential for the Consolidation of Synaptic Plasticity and Memories

3. Arc/Arg3.1 Interacts with the Endocytic Machinery to Regulate AMPA Receptor Trafficking

4. Arc/Arg3.1 Mediates Homeostatic Synaptic Scaling of AMPA Receptors

5. Arc/Arg3.1 Regulates an Endosomal Pathway Essential for Activity-Dependent β-Amyloid Generation

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2. PNMA2 forms immunogenic non-enveloped virus-like capsids associated with paraneoplastic neurological syndrome;Cell;2024-02

3. The Roles of Transposable Elements in Transgenerational Inheritance and Genome Evolution;Epigenetics in Biological Communication;2024

4. Identifying new players in structural synaptic plasticity through dArc1 interrogation;iScience;2023-11

5. Single-cell sequencing of tumor-associated macrophages in a Drosophila model;Frontiers in Immunology;2023-09-19

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