The deacetylation-phosphorylation regulation of SIRT2-SMC1A axis as a mechanism of antimitotic catastrophe in early tumorigenesis

Author:

Yi Fei1ORCID,Zhang Ying2ORCID,Wang Zhijun1ORCID,Wang Zhuo1,Li Ziwei1,Zhou Tingting1,Xu Hongde1ORCID,Liu Jingwei1,Jiang Bo1,Li Xiaoman1,Wang Liang3,Bai Ning1,Guo Qiqiang1,Guan Yi1ORCID,Feng Yanling1,Mao Zhiyong4,Fan Guangjian5ORCID,Zhang Shengping5ORCID,Wang Chuangui5,Cao Longyue6,O’Rourke Brian P.7,Wang Yang8,Wu Yanmei8,Wu Boquan2,You Shilong2,Zhang Naijin2ORCID,Guan Junlin9ORCID,Song Xiaoyu1ORCID,Sun Yingxian2ORCID,Wei Shi10ORCID,Cao Liu1ORCID

Affiliation:

1. Institute of Translational Medicine, Key Laboratory of Cell Biology of Ministry of Public Health, and Key Laboratory of Medical Cell Biology of Ministry of Education, Liaoning Province Collaborative Innovation Center of Aging Related Disease Diagnosis and Treatment and Prevention, China Medical University, , No. 77, Puhe Road, Shenyang North New Area, Shenyang, Liaoning 110122, China.

2. Department of Cardiology, The First Hospital of China Medical University, Shenyang, Liaoning 110001, China.

3. Department of Pathology, College of Basic Medical Sciences, China Medical University, Shenyang, Liaoning Province 110122, China.

4. Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai 200082, China.

5. Institute of Translational Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China.

6. Wilf Family Cardiovascular Research Institute, Department of Medicine (Cardiology), Albert Einstein College of Medicine, Bronx, NY 10461, USA.

7. Department of Physiology and Biophysics, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

8. Panjin Liaohe Oilfield Gem Flower Hospital, Panjin, Liaoning Province 124010, China.

9. Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.

10. Department of Pathology, School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35249-7331, USA.

Abstract

SIRT2-mediated deacetylation of SMC1A promotes its phosphorylation and overcomes the oncogenic stress for tumor cell survival.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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