Topography of transcriptionally active chromatin in glioblastoma

Author:

Xu Liang12ORCID,Chen Ye1ORCID,Huang Yulun345ORCID,Sandanaraj Edwin67ORCID,Yu John S.8ORCID,Lin Ruby Yu-Tong1ORCID,Dakle Pushkar1ORCID,Ke Xin-Yu1,Chong Yuk Kien6,Koh Lynnette69,Mayakonda Anand1ORCID,Nacro Kassoum10ORCID,Hill Jeffrey11ORCID,Huang Mo-Li112,Gery Sigal13,Lim See Wee6,Huang Zhengyun14,Xu Ying14ORCID,Chen Jianxiang151617ORCID,Bai Longchuan1819,Wang Shaomeng18192021,Wakimoto Hiroaki22,Yeo Tseng Tsai23ORCID,Ang Beng Ti2425ORCID,Müschen Markus2627ORCID,Tang Carol6928,Tan Tuan Zea1ORCID,Koeffler H. Phillip11323

Affiliation:

1. Cancer Science Institute of Singapore, National University of Singapore, 117599, Singapore.

2. College of Life Sciences, Zhejiang University, Hangzhou, 310058, China.

3. Department of Neurosurgery, Dushu Lake Hospital Affiliated of Soochow University, Suzhou, 215124, China.

4. Department of Neurosurgery, Medical Center of Soochow University, Suzhou, 215124, China.

5. Department of Neurosurgery, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China.

6. Department of Research, National Neuroscience Institute, 308433, Singapore.

7. Singapore Institute for Clinical Sciences, Agency for Science, Technology, and Research, 117609, Singapore.

8. Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.

9. School of Biological Sciences, Nanyang Technological University, 637551, Singapore.

10. Experimental Drug Development Centre, Agency for Science, Technology and Research, 138670, Singapore.

11. Sussex Drug Discovery Centre, School of Life Sciences, University of Sussex, Brighton BN1 9QJ, UK.

12. School of Biology and Basic Medical Sciences, Soochow University, Suzhou, 215123, China.

13. Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.

14. Cambridge-Suda Genomic Research Center, Soochow University, Suzhou, 215123, China.

15. College of Pharmacy, School of Medicine, Hangzhou Normal University, Hangzhou, 311121, China.

16. Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, 311121, China.

17. Department of Hepatology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, 310015, China.

18. Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.

19. Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA.

20. Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109, USA.

21. Department of Medicinal Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.

22. Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

23. National University Cancer Institute, National University Hospital, 119074, Singapore.

24. Department of Neurosurgery, National Neuroscience Institute, 308433, Singapore.

25. Duke-National University of Singapore Medical School, 169857, Singapore.

26. Center of Molecular and Cellular Oncology, Yale Cancer Center, Yale School of Medicine, New Haven, CT 06511, USA.

27. Department of Immunobiology, Yale University, New Haven, CT 06511, USA.

28. Cancer and Stem Cell Biology Program, Duke-National University of Singapore Medical School, 169857, Singapore.

Abstract

Profiling of active gene-regulatory DNA elements in brain cancer tissues illuminates disease biology and therapeutic targets.

Funder

Howard Hughes Medical Institute

National Cancer Institute

Ministry of Health -Singapore

National University of Singapore

Ministry of Education - Singapore

National Natural Science Foundation of China

Hangzhou Normal University

Jiangsu Province Commission of Health and Family Planning Research funding

Suzhou Science and Technology Development Plan

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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