Association of maternal polygenic risk scores for mental illness with perinatal risk factors for offspring mental illness-Reference-Cited by-同舟云学术

Association of maternal polygenic risk scores for mental illness with perinatal risk factors for offspring mental illness

Published:2022-12-14 Issue:50 Volume:8 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Ratanatharathorn Andrew¹²^ORCID,Chibnik Lori B.²³,Koenen Karestan C.¹²⁴⁵⁶,Weisskopf Marc G.²⁷^ORCID,Roberts Andrea L.⁷^ORCID

Affiliation:

1. Department of Epidemiology, Columbia University Mailman School of Public Health, New York, NY 10032, USA.

2. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.

3. Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA.

4. Department of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.

5. Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.

6. Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA.

7. Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.

Abstract

We examined whether genetic risk for mental illness is associated with known perinatal risk factors for offspring mental illness to determine whether gene-environmental correlation might account for the associations of perinatal factors with mental illness. Among 8983 women with 19,733 pregnancies, we found that genetic risk for mental illness was associated with any smoking during pregnancy [attention-deficit hyperactivity disorder (ADHD) and overall genetic risk], breast-feeding for less than 1 month (ADHD, depression, and overall genetic risk), experience of intimate partner violence in the year before the birth (depression and overall genetic risk), and pregestational overweight or obesity (bipolar disorder). These results indicate that genetic risk may partly account for the association between perinatal conditions and mental illness in offspring.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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