Reduced MC4R signaling alters nociceptive thresholds associated with red hair

Author:

Robinson Kathleen C.1ORCID,Kemény Lajos V.1ORCID,Fell Gillian L.1,Hermann Andrea L.12ORCID,Allouche Jennifer1ORCID,Ding Weihua3,Yekkirala Ajay4,Hsiao Jennifer J.1,Su Mack Y.1,Theodosakis Nicholas1ORCID,Kozak Gabor56ORCID,Takeuchi Yuichi5789ORCID,Shen Shiqian3,Berenyi Antal581011ORCID,Mao Jianren3ORCID,Woolf Clifford J.4ORCID,Fisher David E.1ORCID

Affiliation:

1. Cutaneous Biology Research Center, Department of Dermatology and MGH Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA.

2. Doctoral School of Clinical Medicine, University of Szeged, Szeged 6720, Hungary.

3. MGH Center for Translational Pain Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA.

4. FM Kirby Neurobiology Center, Boston Children’s Hospital, and Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.

5. MTA-SZTE ‘Momentum’ Oscillatory Neuronal Networks Research Group, Department of Physiology, Interdisciplinary Excellence Centre, University of Szeged, Szeged H-6720, Hungary.

6. University Neurology Hospital and Hertie Institute for Clinical Brain Research, Tübingen, Germany

7. Department of Neuropharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603, Japan.

8. Neurocybernetics Excellence Center, University of Szeged, 10 Dom sqr, Szeged 6720, Hungary.

9. Department of Physiology, Osaka City University Graduate School of Medicine, 1-4-3, Asahimachi, Abeno-ku, Osaka 545-8585, Japan.

10. Neuroscience Institute, New York University, New York City, NY 10016, USA.

11. HCEMM-USZ Magnetotherapeutics Research Group, University of Szeged, 10 Dom sqr, Szeged 6720, Hungary.

Abstract

In the red-haired background, altered pain thresholds exist and are explained by distinct OPRM1/MC4R signaling.

Funder

National Institute of Arthritis and Musculoskeletal and Skin Diseases

Melanoma Research Alliance

Dr. Miriam and Sheldon G. Adelson Medical Research Foundation

US-Israel Binational Science Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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