Building block properties govern granular hydrogel mechanics through contact deformations

Author:

Emiroglu Dilara Börte12ORCID,Bekcic Aleksandar1,Dranseikiene Dalia1ORCID,Zhang Xinyu3,Zambelli Tomaso3ORCID,deMello Andrew J.2ORCID,Tibbitt Mark W.1ORCID

Affiliation:

1. Macromolecular Engineering Laboratory, Department of Mechanical and Process Engineering, ETH Zurich, 8092 Zurich, Switzerland.

2. Institute for Chemical and Bioengineering, Department of Chemistry and Applied Biosciences, ETH Zurich, 8093 Zurich, Switzerland.

3. Laboratory of Biosensors and Bioelectronics, Department of Information Technology and Electrical Engineering, ETHZurich, 8093 Zurich, Switzerland.

Abstract

Granular hydrogels have been increasingly exploited in biomedical applications, including wound healing and cardiac repair. Despite their utility, design guidelines for engineering their macroscale properties remain limited, as we do not understand how the properties of granular hydrogels emerge from collective interactions of their microgel building blocks. In this work, we related building block features (stiffness and size) to the macroscale properties of granular hydrogels using contact mechanics. We investigated the mechanics of the microgel packings through dynamic oscillatory rheology. In addition, we modeled the system as a collection of two-body interactions and applied the Zwanzig and Mountain formula to calculate the plateau modulus and viscosity of the granular hydrogels. The calculations agreed with the dynamic mechanical measurements and described how microgel properties and contact deformations define the rheology of granular hydrogels. These results support a rational design framework for improved engineering of this fascinating class of materials.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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