A mathematical model of ctDNA shedding predicts tumor detection size

Author:

Avanzini Stefano1ORCID,Kurtz David M.2ORCID,Chabon Jacob J.34ORCID,Moding Everett J.45ORCID,Hori Sharon Seiko16ORCID,Gambhir Sanjiv Sam14678ORCID,Alizadeh Ash A.234ORCID,Diehn Maximilian345ORCID,Reiter Johannes G.1479ORCID

Affiliation:

1. Canary Center for Cancer Early Detection, Department of Radiology, Stanford University School of Medicine, Palo Alto, CA 94304, USA.

2. Division of Oncology, Division of Hematology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

3. Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

4. Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.

5. Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.

6. Molecular Imaging Program at Stanford, Department of Radiology, Stanford University School of Medicine, Stanford, CA 94305, USA.

7. Bio-X Program, Stanford University, Stanford, CA 94305, USA.

8. Department of Bioengineering and Department of Materials Science and Engineering, Stanford University School of Medicine, Palo Alto, CA 94305, USA.

9. Department of Biomedical Data Science, Biophysics Program, Stanford University, Stanford, CA 94305, USA.

Abstract

A mathematical model of tumor evolution and ctDNA shedding informs new cancer early detection approaches.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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