Human interleukin-4–treated regulatory macrophages promote epithelial wound healing and reduce colitis in a mouse model-Reference-Cited by-同舟云学术

Human interleukin-4–treated regulatory macrophages promote epithelial wound healing and reduce colitis in a mouse model

Published:2020-06-05 Issue:23 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Jayme Timothy S.¹^ORCID,Leung Gabriella¹²^ORCID,Wang Arthur¹,Workentine Matthew L.³^ORCID,Rajeev Sruthi¹^ORCID,Shute Adam¹,Callejas Blanca E.¹^ORCID,Mancini Nicole¹^ORCID,Beck Paul L.⁴^ORCID,Panaccione Remo⁴,McKay Derek M.¹^ORCID

Affiliation:

1. Gastrointestinal Research Group and Inflammation Research Network, Department of Physiology and Pharmacology, Calvin, Joan and Phoebe Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Alberta, Canada.

2. Division of Gastroenterology, Hepatology and Nutrition, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

3. Faculty of Veterinary Medicine, University of Calgary, Calgary, Canada.

4. Gastrointestinal Research Group, Division of Gastroenterology, Cumming School of Medicine, University of Calgary, Calgary, Canada.

Abstract

Human IL-4 macrophages promote epithelial wound recovery and suppress colitis, supporting their use as a cell therapy for IBD.

Funder

Crohn’c Colitis Canada

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference40 articles.