Multiple sclerosis iPS-derived oligodendroglia conserve their properties to functionally interact with axons and glia in vivo

Author:

Mozafari Sabah1234ORCID,Starost Laura56ORCID,Manot-Saillet Blandine78ORCID,Garcia-Diaz Beatriz1234ORCID,Xu Yu Kang T.9ORCID,Roussel Delphine1234,Levy Marion J. F.1234ORCID,Ottoboni Linda10,Kim Kee-Pyo6ORCID,Schöler Hans R.6ORCID,Kennedy Timothy E.9ORCID,Antel Jack P.11ORCID,Martino Gianvito10ORCID,Angulo Maria Cecilia78ORCID,Kuhlmann Tanja56,Baron-Van Evercooren Anne1234ORCID

Affiliation:

1. INSERM, U1127, F-75013 Paris, France.

2. CNRS, UMR 7225, F-75013 Paris, France.

3. Sorbonne Université UPMC Paris 06, UM-75, F-75005, Paris, France.

4. ICM-GH Pitié-Salpêtrière, F-75013, Paris, France.

5. Institute of Neuropathology, University Hospital Münster, 48149 Münster, Germany.

6. Department of Cell and Developmental Biology, Max Planck Institute for Molecular Biomedicine, 48149 Münster, Germany.

7. Institute of Psychiatry and Neuroscience of Paris (IPNP), INSERM, Université de Paris, U1266, F-75014 Paris, France.

8. GHU PARIS Psychiatrie & Neurosciences, Paris, France.

9. McGill Program in Neuroengineering, Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada.

10. Institute of Experimental Neurology-DIBIT 2, Division of Neuroscience, IRCCS San Raffaele Hospital and Vita San Raffaele University, Milan, Italy.

11. Neuroimmunology Unit, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.

Abstract

MS-derived oligodendrocytes conserve their ability to fully interact with axons and glial cells in vivo.

Funder

National Multiple Sclerosis Society

European Committee for Treatment and Research in Multiple Sclerosis

Fondation Leducq

Institut national de la santé et de la recherche médicale

German Research Foundation

Progressive MS Alliance

Institut du Cerveau et de la Moelle épinière

Fondation pour l’aide à la recherche sur la Sclérose en Plaques

French Ministry of Research

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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