A polymeric approach toward resistance-resistant antimicrobial agent with dual-selective mechanisms of action-Reference-Cited by-同舟云学术

A polymeric approach toward resistance-resistant antimicrobial agent with dual-selective mechanisms of action

Published:2021-01-29 Issue:5 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Bai Silei¹²³^ORCID,Wang Jianxue¹²³,Yang Kailing¹²⁴,Zhou Cailing¹²⁴,Xu Yangfan¹²⁴,Song Junfeng¹²³,Gu Yuanxin¹²³,Chen Zheng¹²³,Wang Min¹²³,Shoen Carolyn⁵,Andrade Brenda⁶^ORCID,Cynamon Michael⁵^ORCID,Zhou Kai⁷⁸^ORCID,Wang Hui⁹,Cai Qingyun³,Oldfield Eric⁶,Zimmerman Steven C.⁶^ORCID,Bai Yugang¹²³^ORCID,Feng Xinxin¹²³^ORCID

Affiliation:

1. Institute of Chemical Biology and Nanomedicine, Hunan University, Changsha, Hunan 410082, China.

2. State Key Laboratory of Chem/Biosensing and Chemometrics, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, Hunan University, Changsha, Hunan 410082, China.

3. School of Chemistry and Chemical Engineering, Hunan University, Changsha, Hunan 410082, China.

4. School of Biology, Hunan University, Changsha, Hunan 410082, China.

5. Veterans Affairs Medical Center, Syracuse, NY 13210, USA.

6. Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

7. Shenzhen Institute of Respiratory Diseases, The First Affiliated Hospital of Southern University of Science and Technology (Shenzhen People’s Hospital), Shenzhen, Guangdong 518035, China.

8. The Second Clinical Medical College of Jinan University (Shenzhen People’s Hospital), Shenzhen, Guangdong 518020, China.

9. Department of Clinical Laboratories, Peking University People’s Hospital, Beijing, 100044, China.

Abstract

An oligoamidine with two bacteria-specific mechanisms of action showed broad-spectrum, resistance-resistant antimicrobial effect.

Funder

National Institutes of Health

National Natural Science Foundation of China

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference66 articles.

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3. Challenges of Antibacterial Discovery

4. Resistance-resistant antibiotics

5. L. L. Silver The antibiotic future in Antibacterials J. F. Fisher S. Mobashery M. J. Miller Eds. (Springer Berlin Heidelberg 2017) vol. 1 pp. 31–67.

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