A molecular sensor for cholesterol in the human serotonin 1A receptor-Reference-Cited by-同舟云学术

A molecular sensor for cholesterol in the human serotonin 1A receptor

Published:2021-07-23 Issue:30 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Kumar G. Aditya¹^ORCID,Sarkar Parijat¹^ORCID,Stepniewski Tomasz Maciej²³^ORCID,Jafurulla Md.¹^ORCID,Singh Shishu Pal⁴^ORCID,Selent Jana²^ORCID,Chattopadhyay Amitabha¹^ORCID

Affiliation:

1. CSIR-Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad 500 007, India.

2. Research Programme on Biomedical Informatics (GRIB), Department of Experimental and Health Sciences of Pompeu Fabra University (UPF)-Hospital del Mar Medical Research Institute (IMIM), 08003 Barcelona, Spain.

3. Faculty of Chemistry, Biological and Chemical Research Centre, University of Warsaw, Warsaw, Poland.

4. National Centre for Biological Sciences, UAS-GKVK Campus, Bellary Road, Bengaluru 560 065, India.

Abstract

Serotonin 1A receptor senses membrane cholesterol via a lysine residue in a CRAC motif in transmembrane helix 2.

Funder

Council of Scientific and Industrial Research

SERB Distinguished Fellowship grant

Instituto de Salud Carlos III FEDER

ERA-NET NEURON and Ministry of Economy, Industry and Competitiveness

National Center of Science, Poland

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference72 articles.

1. The Molecular Basis of G Protein–Coupled Receptor Activation

2. New Binding Sites, New Opportunities for GPCR Drug Discovery

3. Cholesterol, the central lipid of mammalian cells

4. How cholesterol interacts with membrane proteins: an exploration of cholesterol-binding sites including CRAC, CARC, and tilted domains

5. Modes of Cholesterol Binding in Membrane Proteins: A Joint Analysis of 73 Crystal Structures

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