Cell fusion potentiates tumor heterogeneity and reveals circulating hybrid cells that correlate with stage and survival-Reference-Cited by-同舟云学术

Cell fusion potentiates tumor heterogeneity and reveals circulating hybrid cells that correlate with stage and survival

Published:2018-09-07 Issue:9 Volume:4 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Gast Charles E.¹^ORCID,Silk Alain D.¹,Zarour Luai²,Riegler Lara³,Burkhart Joshua G.⁴^ORCID,Gustafson Kyle T.⁵⁶^ORCID,Parappilly Michael S.¹,Roh-Johnson Minna⁷,Goodman James R.⁸^ORCID,Olson Brennan¹,Schmidt Mark¹^ORCID,Swain John R.¹^ORCID,Davies Paige S.¹,Shasthri Vidya¹,Iizuka Shinji¹,Flynn Patrick¹^ORCID,Watson Spencer¹^ORCID,Korkola James³⁹^ORCID,Courtneidge Sara A.¹⁹^ORCID,Fischer Jared M.⁵⁹¹⁰^ORCID,Jaboin Jerry⁹¹¹,Billingsley Kevin G.²⁹^ORCID,Lopez Charles D.³⁹,Burchard Julja¹²,Gray Joe⁶⁹^ORCID,Coussens Lisa M.¹⁹^ORCID,Sheppard Brett C.²⁹^ORCID,Wong Melissa H.¹⁹^ORCID

Affiliation:

1. Department of Cell, Developmental and Cancer Biology, Oregon Health & Science University, Portland, OR 97239, USA.

2. Department of Surgery, Oregon Health & Science University, Portland, OR 97239, USA.

3. Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA.

4. Department of Medical Informatics and Clinical Epidemiology, Oregon Health & Science University, Portland, OR 97239, USA.

5. Center for Early Detection Advanced Research, Oregon Health & Science University, Portland, OR 97239, USA.

6. Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR 97239, USA.

7. Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA.

8. Department of Physiology and Pharmacology, Oregon Health & Science University, Portland, OR 97239, USA.

9. Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA.

10. Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR 97239, USA.

11. Department of Radiation Medicine, Oregon Health & Science University, Portland, OR 97239, USA.

12. Department of Computational Biology, Oregon Health & Science University, Portland, OR 97239, USA.

Abstract

Peripheral blood MФ–cancer cell fusion hybrids identified in cancer patients correlate with disease stage and overall survival.

Funder

NIH/NCI

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference56 articles.

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3. Bone marrow-derived cells fuse with normal and transformed intestinal stem cells;Rizvi A. Z.;Proc. Natl. Acad. Sci. U.S.A.,2006

4. Inflammation and proliferation act together to mediate intestinal cell fusion;Davies P. S.;PLOS ONE,2009

5. Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes;Alvarez-Dolado M.;Nature,2003

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