GADL1 is a multifunctional decarboxylase with tissue-specific roles in β-alanine and carnosine production-Reference-Cited by-同舟云学术

GADL1 is a multifunctional decarboxylase with tissue-specific roles in β-alanine and carnosine production

Published:2020-07-17 Issue:29 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Mahootchi Elaheh¹^ORCID,Cannon Homaei Selina¹²^ORCID,Kleppe Rune²^ORCID,Winge Ingeborg¹,Hegvik Tor-Arne¹^ORCID,Megias-Perez Roberto¹^ORCID,Totland Christian³⁴^ORCID,Mogavero Floriana⁵^ORCID,Baumann Anne¹,Glennon Jeffrey Colm⁵⁶^ORCID,Miletic Hrvoje¹⁷^ORCID,Kursula Petri¹⁸^ORCID,Haavik Jan¹²^ORCID

Affiliation:

1. Department of Biomedicine, University of Bergen, Bergen, Norway.

2. Division of Psychiatry, Haukeland University Hospital, Bergen, Norway.

3. Department of Chemistry, University of Bergen, Bergen, Norway.

4. Norwegian Geotechnical Institute, Oslo, Norway.

5. Department of Cognitive Neuroscience, Donders Institute for Brain Cognition and Behavior, Radboud University Medical Center, Nijmegen, Netherlands.

6. Conway Institute of Biomolecular and Biomedical Research, School of Medicine, University College Dublin, Belfield, Dublin 4, Ireland.

7. Department of Pathology, Haukeland University Hospital, Bergen, Norway.

8. Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland.

Abstract

Mice lacking the enzyme GADL1 have reduced levels of carnosine and anserine peptides and increased oxidative stress markers.

Funder

Stiftelsen Kristian Gerhard Jebsen

Research Council of Norway

The Regional Health Authority of Western Norway

Trond Mohn Stiftelse

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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4. Carnosinemia — A new metabolic disorder associated with neurologic disease and mental defect;Perry T. L.;N. Engl. J. Med.,1967

5. Neurological disease in a child with carnosinase deficiency;Wisniewski K.;Neuropediatrics,1981

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