Inhibition of histone methyltransferase DOT1L silences ERα gene and blocks proliferation of antiestrogen-resistant breast cancer cells-Reference-Cited by-同舟云学术

Inhibition of histone methyltransferase DOT1L silences ERα gene and blocks proliferation of antiestrogen-resistant breast cancer cells

Published:2019-02 Issue:2 Volume:5 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Nassa Giovanni¹^ORCID,Salvati Annamaria¹^ORCID,Tarallo Roberta¹^ORCID,Gigantino Valerio¹^ORCID,Alexandrova Elena¹²^ORCID,Memoli Domenico¹^ORCID,Sellitto Assunta¹^ORCID,Rizzo Francesca¹^ORCID,Malanga Donatella³,Mirante Teresa³,Morelli Eugenio³,Nees Matthias⁴,Åkerfelt Malin⁴^ORCID,Kangaspeska Sara⁵,Nyman Tuula A.⁶^ORCID,Milanesi Luciano⁷^ORCID,Giurato Giorgio¹²^ORCID,Weisz Alessandro¹^ORCID

Affiliation:

1. Laboratory of Molecular Medicine and Genomics, Department of Medicine, Surgery and Dentistry, “Scuola Medica Salernitana”, University of Salerno, Baronissi, SA, Italy.

2. Genomix4Life Srl, University of Salerno, Baronissi, SA, Italy.

3. Department of Experimental and Clinical Medicine, University “Magna Graecia”, Catanzaro (CZ), Italy.

4. Institute of Biomedicine, University of Turku, Turku, Finland.

5. Institute for Molecular Medicine, Biomedicum 2U, Helsinki, Finland.

6. Department of Immunology, Institute of Clinical Medicine, University of Oslo and Rikshospitalet Oslo, Oslo, Norway.

7. Institute of Biomedical Technologies, National Research Council, Segrate, MI, Italy.

Abstract

Pharmacological inhibition of DOT1L blocks estrogen receptor signaling in breast cancer.

Funder

Ministero dell’Istruzione, dell’Università e della Ricerca

Associazione Italiana per la Ricerca sul Cancro

Università degli Studi di Salerno