Trisomy 21–induced dysregulation of microglial homeostasis in Alzheimer’s brains is mediated by USP25-Reference-Cited by-全球学者库

Trisomy 21–induced dysregulation of microglial homeostasis in Alzheimer’s brains is mediated by USP25

Published:2021-01 Issue:1 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Zheng Qiuyang¹^ORCID,Li Guilin¹^ORCID,Wang Shihua¹²^ORCID,Zhou Ying³^ORCID,Liu Ke³^ORCID,Gao Yue¹^ORCID,Zhou Yulin⁴,Zheng Liangkai⁴,Zhu Lin¹,Deng Qingfang¹,Wu Meiling¹,Di Anjie¹,Zhang Lishan¹,Zhao Yingjun¹,Zhang Hongfeng¹,Sun Hao¹,Dong Chen⁵^ORCID,Xu Huaxi¹⁶^ORCID,Wang Xin¹^ORCID

Affiliation:

1. State Key Laboratory of Cellular Stress Biology, Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, Fujian 361005, China.

2. School of Medicine, Xizang Minzu University, Xianyang, Shaanxi 712082, China.

3. Department of Translational Medicine, School of Medicine, Xiamen University, Xiamen, Fujian 361005, China.

4. Women and Children’s Hospital, School of Medicine, Xiamen University, Xiamen, Fujian 361003, China.

5. Institute for Immunology, School of Medicine, Tsinghua University, Beijing 100084, China.

6. Center for Brain Sciences, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian 361003, China.

Abstract

Trisomy 21 induces microglial dysregulation in the Alzheimer’s brain through the perturbation of the ubiquitin-proteasome system.

Funder

National Natural Science Foundation of China

National Key Research and Development Program of China Stem Cell and Translational Research

Natural Science Foundation of Fujian Province of China

Fundamental Research Funds for the Chinese Central Universities

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference57 articles.