Type 2 immunity induced by bladder extracellular matrix enhances corneal wound healing

Author:

Wang Xiaokun1ORCID,Chung Liam12ORCID,Hooks Joshua1,Maestas David R.1ORCID,Lebid Andriana2ORCID,Andorko James I.12ORCID,Huleihel Luai34,Chin Alexander F.1ORCID,Wolf Matthew156ORCID,Remlinger Nathaniel T.3,Stepp Mary Ann7ORCID,Housseau Franck2ORCID,Elisseeff Jennifer H.125ORCID

Affiliation:

1. Translational Tissue Engineering Center, Johns Hopkins School of Medicine, Baltimore, MD 21231, USA.

2. Bloomberg-Kimmel Institute for Cancer Immunotherapy and Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.

3. ACell Inc., Columbia, MD 21046, USA.

4. McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA.

5. Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.

6. Laboratory of Cancer Immunometabolism, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA.

7. Department of Anatomy and Cell Biology and Department of Ophthalmology, School of Medicine and Health Sciences, George Washington University, Washington DC 20037, USA.

Abstract

Extracellular matrix particulate stimulates local and peripheral type 2 immune response to enhance corneal wound healing.

Funder

National Institutes of Health

National Eye Institute

National Science Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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