The ancestral retinoic acid receptor was a low-affinity sensor triggering neuronal differentiation

Author:

Handberg-Thorsager Mette1ORCID,Gutierrez-Mazariegos Juliana2,Arold Stefan T.3ORCID,Kumar Nadendla Eswar4,Bertucci Paola Y.1ORCID,Germain Pierre4,Tomançak Pavel5,Pierzchalski Keely6ORCID,Jones Jace W.6ORCID,Albalat Ricard7ORCID,Kane Maureen A.6ORCID,Bourguet William4,Laudet Vincent2ORCID,Arendt Detlev18ORCID,Schubert Michael9ORCID

Affiliation:

1. Developmental Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69012 Heidelberg, Germany.

2. Molecular Zoology Team, Institut de Génomique Fonctionnelle de Lyon, Université de Lyon, Université Lyon 1, CNRS, Institut National de la Recherche Agronomique, Ecole Normale Supérieure de Lyon, 46 Allée d’Italie, 69364 Lyon Cedex 07, France.

3. King Abdullah University of Science and Technology, Center for Computational Bioscience Research, Division of Biological and Environmental Sciences and Engineering, Thuwal 23955-6900, Saudi Arabia.

4. Centre de Biochimie Structurale, Inserm, CNRS, Université de Montpellier, 29 Rue de Navacelles, 34090 Montpellier, France.

5. Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany.

6. Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, 20 North Pine Street, Baltimore, MD 21201, USA.

7. Departament de Genètica, Microbiologia i Estadística, Institut de Recerca de la Biodiversitat (IRBio), Facultat de Biologia, Universitat de Barcelona, Avinguda Diagonal 643, 08028 Barcelona, Spain.

8. Centre for Organismal Studies, University of Heidelberg, Im Neuenheimer Feld 230, 69120 Heidelberg, Germany.

9. Sorbonne Universités, Université Pierre et Marie Curie (UPMC) Université Paris 06, CNRS, Laboratoire de Biologie du Développement de Villefranche-sur-Mer, Observatoire Océanologique de Villefranche-sur-Mer, 181 Chemin du Lazaret, 06230 Villefranche-sur-Mer, France.

Abstract

Vitamin A–dependent intercellular signaling was originally regulated by a low-affinity sensor and acted in neural development.

Funder

European Research Council

Agence Nationale de la Recherche

Ministerio de Economía y Competitividad

King Abdullah University of Science and Technology

Ministerio de Ciencia e Innovación

European Molecular Biology Laboratory

French Infrastructure for Integrated Structural Biology

ERC

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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