Inhalable Nanobody (PiN-21) prevents and treats SARS-CoV-2 infections in Syrian hamsters at ultra-low doses-Reference-Cited by-同舟云学术

Inhalable Nanobody (PiN-21) prevents and treats SARS-CoV-2 infections in Syrian hamsters at ultra-low doses

Published:2021-05-28 Issue:22 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Nambulli Sham¹²^ORCID,Xiang Yufei³^ORCID,Tilston-Lunel Natasha L.¹²^ORCID,Rennick Linda J.¹²^ORCID,Sang Zhe³⁴^ORCID,Klimstra William B.¹²⁵,Reed Douglas S.¹⁵^ORCID,Crossland Nicholas A.⁶⁷^ORCID,Shi Yi³⁴^ORCID,Duprex W. Paul¹²^ORCID

Affiliation:

1. Center for Vaccine Research, University of Pittsburgh, Pittsburgh, PA, USA.

2. Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA, USA.

3. Department of Cell Biology, University of Pittsburgh, Pittsburgh, PA, USA.

4. University of Pittsburgh–Carnegie Mellon University Program in Computational Biology, Pittsburgh, PA, USA.

5. Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA.

6. Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA, USA.

7. National Emerging Infectious Diseases Laboratories, Boston University, Boston, MA, USA.

Abstract

Aerosol delivery of an ultrapotent nanobody efficiently prevents and treats SARS-CoV-2 infection.

Funder

National Institute of General Medical Sciences

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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