The fluid shear stress sensor TRPM7 regulates tumor cell intravasation-Reference-Cited by-同舟云学术

The fluid shear stress sensor TRPM7 regulates tumor cell intravasation

Published:2021-07-09 Issue:28 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Yankaskas Christopher L.¹²^ORCID,Bera Kaustav¹²^ORCID,Stoletov Konstantin³,Serra Selma A.⁴^ORCID,Carrillo-Garcia Julia⁴^ORCID,Tuntithavornwat Soontorn¹²,Mistriotis Panagiotis¹²⁵^ORCID,Lewis John D.³^ORCID,Valverde Miguel A.⁴^ORCID,Konstantopoulos Konstantinos¹²⁶⁷^ORCID

Affiliation:

1. Department of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, MD 21218, USA.

2. Johns Hopkins Institute for NanoBioTechnology, The Johns Hopkins University, Baltimore, MD 21218, USA.

3. Department of Oncology, University of Alberta, Edmonton, AB T6G 2E1, Canada.

4. Laboratory of Molecular Physiology, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, 08003 Barcelona, Spain.

5. Department of Chemical Engineering, Auburn University, Auburn, AL 36849, USA.

6. Department of Biomedical Engineering, The Johns Hopkins University, Baltimore, MD 21218, USA.

7. Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Abstract

Fluid shear sensing via TRPM7 limits tumor cell intravasation by activating RhoA/myosin and calmodulin/IQGAP1/Cdc42 pathways.

Funder

National Institutes of Health

Alberta Cancer Foundation

Spanish Ministry of Science, Education and Universities

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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