Secondary nucleation and elongation occur at different sites on Alzheimer’s amyloid-β aggregates-Reference-Cited by-同舟云学术

Secondary nucleation and elongation occur at different sites on Alzheimer’s amyloid-β aggregates

Published:2019-04-05 Issue:4 Volume:5 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Scheidt Tom¹^ORCID,Łapińska Urszula¹,Kumita Janet R.¹,Whiten Daniel R.¹²^ORCID,Klenerman David¹^ORCID,Wilson Mark R.²^ORCID,Cohen Samuel I. A.¹,Linse Sara³^ORCID,Vendruscolo Michele¹^ORCID,Dobson Christopher M.¹^ORCID,Knowles Tuomas P. J.¹⁴,Arosio Paolo¹⁵^ORCID

Affiliation:

1. Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK.

2. School of Biological Sciences, University of Wollongong, Wollongong, New South Wales, Australia.

3. Department of Biochemistry and Structural Biology, Lund University, Box 124, SE221 00 Lund, Sweden.

4. Cavendish Laboratory, University of Cambridge, J J Thomson Avenue, Cambridge CB3 0HE, UK.

5. Department of Chemistry and Applied Biosciences, ETH Zurich, Vladimir-Prelog-Weg, 8093 Zurich, Switzerland.

Abstract

Chaperone regulation of individual microscopic events in Aβ42 aggregation reveals the nature of active sites on amyloid fibrils.

Funder

Wellcome Trust

Frances and Augustus Newman Foundation

Seventh Framework Programme

Vetenskapsrådet

BBSRC

PhysProt

EPSRC

Marie Curie Fellowship

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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