Control of lysosomal-mediated cell death by the pH-dependent calcium channel RECS1

Author:

Pihán Philippe123ORCID,Lisbona Fernanda134ORCID,Borgonovo Janina125,Edwards-Jorquera Sandra4ORCID,Nunes-Hasler Paula67ORCID,Castillo Karen8,Kepp Oliver910ORCID,Urra Hery123ORCID,Saarnio Suvi11,Vihinen Helena11ORCID,Carreras-Sureda Amado1236,Forveille Sabrina910,Sauvat Allan910,De Giorgis Daniela8,Pupo Amaury8,Rodríguez Diego A.12ORCID,Quarato Giovanni12ORCID,Sagredo Alfredo123ORCID,Lourido Fernanda4ORCID,Letai Anthony131415ORCID,Latorre Ramon8,Kroemer Guido910161718,Demaurex Nicolas619,Jokitalo Eija11ORCID,Concha Miguel L.125ORCID,Glavic Álvaro4,Green Douglas R.12ORCID,Hetz Claudio12320ORCID

Affiliation:

1. Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile.

2. Center for Geroscience, Brain Health and Metabolism (GERO), Santiago, Chile.

3. Program of Cellular and Molecular Biology, Institute of Biomedical Sciences, University of Chile, Santiago, Chile.

4. Center for Genome Regulation, Faculty of Sciences, University of Chile, Santiago, Chile.

5. Program of Integrative Biology, Institute of Biomedical Sciences, University of Chile, Santiago, Chile.

6. Department of Cell Physiology and Metabolism, University of Geneva, Geneva, Switzerland.

7. Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland.

8. Centro Interdisciplinario de Neurociencia de Valparaíso, Facultad de Ciencias, Universidad de Valparaíso, Valparaíso, Chile.

9. Centre de Recherche des Cordeliers, Equipe labellisée par la Ligue contre le cancer, Université de Paris, Sorbonne Université, Inserm U1138, Institut Universitaire de France, Paris, France.

10. Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, Villejuif, France.

11. Electron Microscopy Unit, Institute of Biotechnology, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.

12. Department of Immunology, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA.

13. Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Dana Building, Room DA-520, Boston, MA 02215-02115, USA.

14. Harvard Medical School, Boston, MA 02215, USA.

15. Department of Medicine, Brigham and Women’s Hospital, Boston, MA 02215, USA.

16. Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, Paris, France.

17. Suzhou Institute for Systems Medicine, Chinese Academy of Medical Sciences, Suzhou, China.

18. Karolinska Institutet, Department of Women’s and Children’s Health, Karolinska University Hospital, Stockholm, Sweden.

19. Centro de Investigación de Estudios Avanzados, Universidad Católica del Maule, Talca, Chile.

20. Buck Institute for Research on Aging, Novato, CA 94945, USA.

Abstract

RECS1, a member of the TMBIM family, triggers lysosomal membrane permeabilization in cells undergoing lysosomal stress.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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