Natural polymorphism of Ym1 regulates pneumonitis through alternative activation of macrophages

Author:

Zhu Wenhua1234ORCID,Lönnblom Erik4,Förster Michael4,Johannesson Martina4ORCID,Tao Pei12,Meng Liesu1234ORCID,Lu Shemin124ORCID,Holmdahl Rikard34ORCID

Affiliation:

1. Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Xi’an Jiaotong University Health Science Center, 710061 Xi’an, China.

2. Key Laboratory of Environment and Genes Related to Diseases (Xi’an Jiaotong University), Ministry of Education of China, 710061 Xi’an, China.

3. The National Local Joint Engineering Research Center of Biodiagnostics and Biotherapy, the Second Affiliated Hospital of Xi’an Jiaotong University, 710004 Xi’an, China.

4. Section for Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm 171 77, Sweden.

Abstract

Ym1 polymorphism regulates alternative activation of macrophages leading to variable susceptibility to inflammatory diseases.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Shaanxi Province

Fundamental Research Funds for the Central Universities

The swedish Research Council

Knut and Alice Wallenberg foundation

Swedish Strategic Science Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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