A novel P300 inhibitor reverses DUX4-mediated global histone H3 hyperacetylation, target gene expression, and cell death-Reference-Cited by-同舟云学术

A novel P300 inhibitor reverses DUX4-mediated global histone H3 hyperacetylation, target gene expression, and cell death

Published:2019-09-06 Issue:9 Volume:5 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Bosnakovski Darko¹²³^ORCID,da Silva Meiricris T.¹²^ORCID,Sunny Sithara T.¹²^ORCID,Ener Elizabeth T.¹²^ORCID,Toso Erik A.¹²,Yuan Ce⁴^ORCID,Cui Ziyou¹²^ORCID,Walters Michael A.⁵^ORCID,Jadhav Ajit⁶^ORCID,Kyba Michael¹²^ORCID

Affiliation:

1. Lillehei Heart Institute, University of Minnesota, Minneapolis, MN 55455, USA.

2. Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA.

3. Faculty of Medical Sciences, University Goce Delcev—Štip, Štip 2000, Republic of North Macedonia.

4. Bioinformatics and Computational Biology Program, University of Minnesota, Minneapolis, MN 55455, USA.

5. Institute for Therapeutics Discovery and Development, University of Minnesota, Minneapolis, MN 55455, USA.

6. National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA.

Abstract

DUX4 drives global histone H3 hyperacetylation; and a new P300 inhibitor, iP300w, blocks DUX4-mediated transcription and toxicity.

Funder

National Institute of Arthritis and Musculoskeletal and Skin Diseases

FSH Society

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference38 articles.

1. Population-based incidence and prevalence of facioscapulohumeral dystrophy

2. Hypomethylation of D4Z4 in 4q-linked and non-4q-linked facioscapulohumeral muscular dystrophy;van Overveld P. G. M.;Nat. Genet.,2003

3. FSHD associated DNA rearrangements are due to deletions of integral copies of a 3.2 kb tandemly repeated unit;Van Deutekom J. C. T.;Hum. Mol. Genet.,1993

4. Digenic inheritance of an SMCHD1 mutation and an FSHD-permissive D4Z4 allele causes facioscapulohumeral muscular dystrophy type 2

5. A Unifying Genetic Model for Facioscapulohumeral Muscular Dystrophy

Cited by 48 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Quantifying anti-DUX4 therapy for facioscapulohumeral muscular dystrophy;2024-08-15

2. CBP/p300 lysine acetyltransferases inhibit HIV-1 expression in latently infected T-cells;2024-07-06

3. Pharmacotherapeutic Approaches to Treatment of Muscular Dystrophies;Biomolecules;2023-10-17

4. Antagonism among DUX family members evolved from an ancestral toxic single homeodomain protein;iScience;2023-10

5. Comparative Analysis of Drug-like EP300/CREBBP Acetyltransferase Inhibitors;ACS Chemical Biology;2023-09-22