Structure and mechanism of bactericidal mammalian perforin-2, an ancient agent of innate immunity-Reference-Cited by-同舟云学术

Structure and mechanism of bactericidal mammalian perforin-2, an ancient agent of innate immunity

Published:2020-01-31 Issue:5 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Ni Tao¹^ORCID,Jiao Fang²^ORCID,Yu Xiulian¹³^ORCID,Aden Saša⁴^ORCID,Ginger Lucy¹,Williams Sophie I.¹⁵^ORCID,Bai Fangfang⁶,Pražák Vojtěch¹^ORCID,Karia Dimple¹^ORCID,Stansfeld Phillip⁵^ORCID,Zhang Peijun¹^ORCID,Munson George⁶^ORCID,Anderluh Gregor⁴^ORCID,Scheuring Simon²⁷^ORCID,Gilbert Robert J. C.¹³^ORCID

Affiliation:

1. Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.

2. Department of Anesthesiology, Weill Cornell Medical College, 1300 York Ave., New York, NY 10065, USA.

3. Calleva Research Centre for Evolution and Human Sciences, Magdalen College, University of Oxford, Oxford OX1 4AU, UK.

4. Department of Molecular Biology and Nanobiotechnology, National Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana, Slovenia.

5. Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK.

6. Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.

7. Department of Physiology and Biophysics, Weill Cornell Medical College, 1300 York Ave., New York, NY 10065, USA.

Abstract

Bactericidal perforin-2 assembles an inactivated pre-pore complex and undergoes a 180° reconfiguration for membrane attack.

Funder

Wellcome Trust

Medical Research Council

Biotechnology and Biological Sciences Research Council

Slovenian Research Agency

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference57 articles.

1. Perforin oligomers form arcs in cellular membranes: a locus for intracellular delivery of granzymes

2. Real-time visualization of perforin nanopore assembly

3. Structural basis of complement membrane attack complex formation

4. Human Perforin Employs Different Avenues to Damage Membranes

5. Membrane pore formation at protein–lipid interfaces

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