Global ubiquitylation analysis of mitochondria in primary neurons identifies endogenous Parkin targets following activation of PINK1-Reference-Cited by-同舟云学术

Global ubiquitylation analysis of mitochondria in primary neurons identifies endogenous Parkin targets following activation of PINK1

Published:2021-11-12 Issue:46 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Antico Odetta¹^ORCID,Ordureau Alban²^ORCID,Stevens Michael¹^ORCID,Singh Francois¹^ORCID,Nirujogi Raja S.¹³,Gierlinski Marek⁴^ORCID,Barini Erica¹^ORCID,Rickwood Mollie L.¹^ORCID,Prescott Alan⁵^ORCID,Toth Rachel¹^ORCID,Ganley Ian G.¹^ORCID,Harper J. Wade²³^ORCID,Muqit Miratul M. K.¹³^ORCID

Affiliation:

1. MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.

2. Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.

3. Aligning Science Across Parkinson’s (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA.

4. Data Analysis Group, Division of Computational Biology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.

5. Dundee Imaging Facility, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.

Abstract

Identification of neuronal targets of PD-linked enzyme Parkin by quantitative ubiquitin-based proteomics.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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