Bioinspired two-in-one nanotransistor sensor for the simultaneous measurements of electrical and mechanical cellular responses

Author:

Gao Hongyan1ORCID,Yang Feiyu2,Sattari Kianoosh3ORCID,Du Xian24ORCID,Fu Tianda1ORCID,Fu Shuai1,Liu Xiaomeng1ORCID,Lin Jian3ORCID,Sun Yubing245ORCID,Yao Jun145ORCID

Affiliation:

1. Department of Electrical and Computer Engineering, University of Massachusetts, Amherst, Amherst, MA 01003, USA.

2. Department of Mechanical and Industrial Engineering, University of Massachusetts, Amherst, Amherst, MA 01003, USA.

3. Department of Mechanical and Aerospace Engineering, University of Missouri, Columbia, MO 65211, USA.

4. Institute for Applied Life Sciences, University of Massachusetts, Amherst, Amherst, MA 01003, USA.

5. Department of Biomedical Engineering, University of Massachusetts, Amherst, Amherst, MA 01003, USA.

Abstract

The excitation-contraction dynamics in cardiac tissue are the most important physiological parameters for assessing developmental state. We demonstrate integrated nanoelectronic sensors capable of simultaneously probing electrical and mechanical cellular responses. The sensor is configured from a three-dimensional nanotransistor with its conduction channel protruding out of the plane. The structure promotes not only a tight seal with the cell for detecting action potential via field effect but also a close mechanical coupling for detecting cellular force via piezoresistive effect. Arrays of nanotransistors are integrated to realize label-free, submillisecond, and scalable interrogation of correlated cell dynamics, showing advantages in tracking and differentiating cell states in drug studies. The sensor can further decode vector information in cellular motion beyond typical scalar information acquired at the tissue level, hence offering an improved tool for cell mechanics studies. The sensor enables not only improved bioelectronic detections but also reduced invasiveness through the two-in-one converging integration.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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