CHK2-FOXK axis promotes transcriptional control of autophagy programs-Reference-Cited by-同舟云学术

CHK2-FOXK axis promotes transcriptional control of autophagy programs

Published:2020-01-03 Issue:1 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Chen Yuping¹²^ORCID,Wu Jinhuan¹²^ORCID,Liang Guang³,Geng Guohe³,Zhao Fei⁴,Yin Ping⁴,Nowsheen Somaira⁴^ORCID,Wu Chengming¹²,Li Yunhui¹²^ORCID,Li Lei¹²^ORCID,Kim Wootae⁴,Zhou Qin⁴,Huang Jinzhou⁴,Liu Jiaqi⁴,Zhang Chao⁴,Guo Guijie⁴,Deng Min⁴,Tu Xinyi⁴,Gao Xiumei⁵^ORCID,Liu Zhongmin¹²^ORCID,Chen Yihan¹²^ORCID,Lou Zhenkun⁴,Luo Kuntian¹²,Yuan Jian¹²^ORCID

Affiliation:

1. Research Center for Translational Medicine, East Hospital, Tongji University School of Medicine, Shanghai 200120, China.

2. Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine, Shanghai 200120, China.

3. School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.

4. Department of Oncology, Mayo Clinic, Rochester, MN 55905, USA.

5. Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 300193 Tianjin, China.

Abstract

We clarify that DNA damage triggers autophagy by CHK2-FOXK axis, and misregulation of this pathway leads to chemoresistance.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference36 articles.

1. Autophagy delays apoptotic death in breast cancer cells following DNA damage

2. Autophagy as a mediator of chemotherapy-induced cell death in cancer

3. Microautophagy: lesser-known self-eating

4. PARP-1 is involved in autophagy induced by DNA damage

5. Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment

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