Misexpression of genes lacking CpG islands drives degenerative changes during aging-Reference-Cited by-同舟云学术

Misexpression of genes lacking CpG islands drives degenerative changes during aging

Published:2021-12-17 Issue:51 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Lee Jun-Yeong¹^ORCID,Davis Ian¹,Youth Elliot H. H.¹²^ORCID,Kim Jonghwan³^ORCID,Churchill Gary⁴^ORCID,Godwin James¹⁴^ORCID,Korstanje Ron⁴^ORCID,Beck Samuel¹^ORCID

Affiliation:

1. Davis Center for Regenerative Biology and Medicine, MDI Biological Laboratory, Bar Harbor, ME 04609, USA.

2. Brown University, Providence, RI 02912, USA.

3. Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA.

4. The Jackson Laboratory, Bar Harbor, ME 04609, USA.

Abstract

Disrupted nuclear architecture triggers misexpression of genes lacking CpG islands and physiological deterioration during aging.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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