Emerging SARS-CoV-2 variants of concern evade humoral immune responses from infection and vaccination

Author:

Caniels Tom G.1ORCID,Bontjer Ilja1ORCID,van der Straten Karlijn12ORCID,Poniman Meliawati1ORCID,Burger Judith A.1,Appelman Brent3ORCID,Lavell A. H. Ayesha4ORCID,Oomen Melissa1,Godeke Gert-Jan5,Valle Coralie5ORCID,Mögling Ramona5,van Willigen Hugo D. G.1,Wynberg Elke67,Schinkel Michiel3ORCID,van Vught Lonneke A.3,Guerra Denise1ORCID,Snitselaar Jonne L.1,Chaturbhuj Devidas N.8ORCID,Cuella Martin Isabel1ORCID,Moore John P.8ORCID,de Jong Menno D.1ORCID,Reusken Chantal5ORCID,Sikkens Jonne J.4ORCID,Bomers Marije K.4ORCID,de Bree Godelieve J.2ORCID,van Gils Marit J.1ORCID,Eggink Dirk15ORCID,Sanders Rogier W.18ORCID,

Affiliation:

1. Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, Amsterdam, Netherlands.

2. Department of Internal Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, Amsterdam, Netherlands.

3. Center for Experimental and Molecular Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, Amsterdam, Netherlands.

4. Department of Internal Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Institute for Infection and Immunity, Amsterdam, Netherlands.

5. Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, Netherlands.

6. Department of Infectious Diseases, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, Amsterdam, Netherlands.

7. Public Health Service of Amsterdam, Amsterdam, Netherlands.

8. Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY, USA.

Abstract

Antibodies of convalescent COVID-19 patients and vaccine recipients show reduced recognition of SARS-CoV-2 variants of concern.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference47 articles.

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3. Preliminary genomic characterisation of an emergent SARS-CoV-2 lineage in the UK defined by a novel set of spike mutations;Rambaut A.;Genom. Epidemiol.,2020

4. Detection of a SARS-CoV-2 variant of concern in South Africa

5. N. R. Faria I. M. Claro D. Candido L. A. Moyses Franco P. S. Andrade T. M. Coletti C. A. M. Silva F. C. Sales E. R. Manuli R. S. Aguiar Others “Genomic characterisation of an emergent SARS-CoV-2 lineage in Manaus: Preliminary findings” (2021); www.icpcovid.com/sites/default/files/2021-01/Ep%20102-1%20Genomic%20characterisation%20of%20an%20emergent%20SARS-CoV-2%20lineage%20in%20Manaus%20Genomic%20Epidemiology%20-%20Virological.pdf.

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