Hyaluronic acid conjugates for topical treatment of skin cancer lesions

Author:

Krishnan Vinu12ORCID,Peng Kevin12ORCID,Sarode Apoorva12ORCID,Prakash Supriya12ORCID,Zhao Zongmin12ORCID,Filippov Sergey K.1ORCID,Todorova Kristina3,Sell Brittney R.4ORCID,Lujano Omar5ORCID,Bakre Shirin1,Pusuluri Anusha12,Vogus Douglas12ORCID,Tsai Kenneth Y.4ORCID,Mandinova Anna367,Mitragotri Samir12ORCID

Affiliation:

1. School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.

2. Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA.

3. Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Building 149 13th Street, Charlestown, MA 02129, USA.

4. Departments of Anatomic Pathology and Tumor Biology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.

5. Department of Molecular, Cellular, and Developmental Biology (MCDB), University of California, Santa Barbara, Santa Barbara, CA 93117, USA.

6. Broad Institute of Harvard and MIT, 7 Cambridge Center, MA 02142, USA.

7. Harvard Stem Cell Institute, 7 Divinity Avenue, Cambridge, MA 02138, USA.

Abstract

Polymer-drug conjugates are developed for the topical ratiometric delivery of a synergistic drug pair to treat skin cancers.

Funder

U.S. Department of Energy

Harvard School of Engineering and Applied Sciences

Hansjörg Wyss Institute for Biologically Inspired Engineering, Harvard University

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference43 articles.

1. American Academy of Dermatology “Incidence Rate—Skin Cancer” (American Academy of Dermatology Association 2021); www.aad.org/media/stats-skin-cancer.

2. Epidemiological trends in skin cancer

3. Non-metastatic non-melanoma skin cancers: Our 3 years of clinical experiences;Sari E.;World J. Plast Surg.,2017

4. Nicotinamide found to reduce the rate of nonmelanoma skin cancers in high-risk patients

5. Recent advances in field cancerization and management of multiple cutaneous squamous cell carcinomas

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