Newly developed reversible MAO-B inhibitor circumvents the shortcomings of irreversible inhibitors in Alzheimer’s disease-Reference-Cited by-同舟云学术

Newly developed reversible MAO-B inhibitor circumvents the shortcomings of irreversible inhibitors in Alzheimer’s disease

Published:2019-03 Issue:3 Volume:5 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Park Jong-Hyun¹^ORCID,Ju Yeon Ha²³⁴^ORCID,Choi Ji Won¹,Song Hyo Jung¹^ORCID,Jang Bo Ko¹^ORCID,Woo Junsung²⁴,Chun Heejung⁴^ORCID,Kim Hyeon Jeong¹⁵,Shin Su Jeong¹⁵,Yarishkin Oleg²,Jo Seonmi²,Park Mijeong⁶^ORCID,Yeon Seul Ki¹⁵^ORCID,Kim Siwon¹³^ORCID,Kim Jeongyeon²,Nam Min-Ho²⁴^ORCID,Londhe Ashwini M.¹³^ORCID,Kim Jina⁷^ORCID,Cho Sung Jin⁷^ORCID,Cho Suengmok⁸^ORCID,Lee Changho⁸,Hwang Sung Yeoun⁹^ORCID,Kim Sang Wook⁹^ORCID,Oh Soo-Jin¹⁴^ORCID,Cho Jeiwon⁶^ORCID,Pae Ae Nim¹³,Lee C. Justin²³⁴¹⁰^ORCID,Park Ki Duk¹³¹¹^ORCID

Affiliation:

1. Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea.

2. Center for Neuroscience and Functional Connectomics, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea.

3. Division of Bio-Medical Science &Technology, KIST School, Korea University of Science and Technology, Seoul 02792, Republic of Korea.

4. Center for Glia-Neuron Interaction, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea.

5. Department of Biotechnology, Yonsei University, Seoul 03722, Republic of Korea.

6. Department of Medical Science, College of Medicine, Catholic Kwandong University and International St. Mary’s Hospital, Incheon 22711, Republic of Korea.

7. New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu 41061, Republic of Korea.

8. Department of Food Science and Technology, Pukyong National University, Busan 48513, Republic of Korea.

9. KEMIMEDI & MEGABIOWOOD, 5F Hanil Bldg, Nonhyeon-ro 652, Seoul 06106, Republic of Korea.

10. Center for Cognition and Sociality, Institute for Basic Science, Daejeon 34126, Republic of Korea.

11. KHU-KIST Department of Converging Science and Technology, Kyung Hee University, Seoul 02447, Republic of Korea.

Abstract

KDS2010, a MAO-B inhibitor, shows a long-lasting effect in alleviating memory impairment in an Alzheimer’s disease mouse model.

Funder

Korea Food Research Institute

National Research Foundation of Korea

Korea Drug Development Fund

Korean National Research Foundation

National research of science & technology

KIST Institutional Grant

KU-KIST Graduate School of Science and Technology program

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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