Metabolically engineered stem cell–derived exosomes to regulate macrophage heterogeneity in rheumatoid arthritis

Author:

You Dong Gil1ORCID,Lim Gyeong Taek1ORCID,Kwon Seunglee1ORCID,Um Wooram1ORCID,Oh Byeong Hoon1ORCID,Song Seok Ho1ORCID,Lee Jungmi1ORCID,Jo Dong-Gyu234ORCID,Cho Yong Woo45,Park Jae Hyung124ORCID

Affiliation:

1. School of Chemical Engineering, College of Engineering, Sungkyunkwan University, 2066 Seobu-ro, Jangan-gu, Suwon 16419, Republic of Korea.

2. Biomedical Institute for Convergence at SKKU (BICS), Sungkyunkwan University, 2066 Seobu-ro, Jangan-gu, Suwon 16419, Republic of Korea.

3. School of Pharmacy, Sungkyunkwan University, 2066 Seobu-ro, Jangan-gu, Suwon 16419, Republic of Korea.

4. ExoStemTech Inc., 55 Hanyangdaehak-ro, Sangnok-gu, Ansan 15588, Republic of Korea.

5. Department of Chemical Engineering, Hanyang University, 55 Hanyangdaehak-ro, Sangnok-gu, Ansan 15588, Republic of Korea.

Abstract

Surface engineering of exosomes enhances the therapeutic efficacy of rheumatoid arthritis by macrophage reprogramming.

Funder

Korea Health Industry Development Institute

Korea Basic Science Institute

National Research Foundation of Korea

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference48 articles.

1. Platelets: emerging facilitators of cellular crosstalk in rheumatoid arthritis

2. Therapeutic strategies for rheumatoid arthritis

3. Fortune Business Insights (2019); www.fortunebusinessinsights.com/industry-reports/rheumatoid-arthritis-therapeutics-market-100488.

4. Rheumatoid arthritis

5. Macrophage heterogeneity in the context of rheumatoid arthritis

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