Longitudinal tracking of neuronal mitochondria delineates PINK1/Parkin-dependent mechanisms of mitochondrial recycling and degradation-Reference-Cited by-同舟云学术

Longitudinal tracking of neuronal mitochondria delineates PINK1/Parkin-dependent mechanisms of mitochondrial recycling and degradation

Published:2021-08-06 Issue:32 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Li Huihui¹^ORCID,Doric Zak¹²^ORCID,Berthet Amandine¹^ORCID,Jorgens Danielle M.³^ORCID,Nguyen Mai K.¹^ORCID,Hsieh Ivy⁴,Margulis Julia¹,Fang Rebecca¹²^ORCID,Debnath Jayanta⁴⁵^ORCID,Sesaki Hiromi⁶,Finkbeiner Steve²⁵⁷⁸⁹^ORCID,Huang Eric²⁴⁵^ORCID,Nakamura Ken¹²⁵⁸^ORCID

Affiliation:

1. Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA 94158, USA.

2. Graduate Program in Neuroscience, University of California, San Francisco, San Francisco, CA 94158, USA.

3. Electron Microscope Laboratory, University of California, Berkeley, Berkeley, CA 94720, USA.

4. Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA.

5. Graduate Program in Biomedical Sciences, University of California, San Francisco, San Francisco, CA 94143, USA.

6. Department of Cell Biology, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.

7. Center for Systems and Therapeutics, Gladstone Institutes, University of California, San Francisco, San Francisco, CA 94158, USA.

8. Department of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA.

9. Department of Physiology, University of California, San Francisco, San Francisco, CA 94158, USA.

Abstract

Time-lapse imaging delineates the mitochondrial life cycle in neurons regulated by PINK1 and Parkin.

Funder

National Institutes of Health

Seattle Foundation

Joan and David Traitel Family Trust

Betty Brown’s Family

Burroughs Wellcome Fund

Larry L. Hillblom Foundation

Berkelhammer Award for Excellence in Neuroscience

U.S. Department of Veterans Affairs

Michael J. Fox Foundation for Parkinson’s Research

Taube/Koret Center for Neurodegenerative disease

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference84 articles.

1. Mitochondrial dynamics in neurodegeneration

2. Loss of Mitochondrial Fission Depletes Axonal Mitochondria in Midbrain Dopamine Neurons

3. Loss of Mfn2 results in progressive, retrograde degeneration of dopaminergic neurons in the nigrostriatal circuit

4. Direct Membrane Association Drives Mitochondrial Fission by the Parkinson Disease-associated Protein α-Synuclein

5. Parkinson's disease–associated mutant VPS35 causes mitochondrial dysfunction by recycling DLP1 complexes

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