Claustrum mediates bidirectional and reversible control of stress-induced anxiety responses-Reference-Cited by-同舟云学术

Claustrum mediates bidirectional and reversible control of stress-induced anxiety responses

Published:2022-03-18 Issue:11 Volume:8 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Niu Misaki¹^ORCID,Kasai Atsushi¹^ORCID,Tanuma Masato¹,Seiriki Kaoru¹²,Igarashi Hisato¹,Kuwaki Takahiro¹,Nagayasu Kazuki¹³,Miyaji Keita¹,Ueno Hiroki¹,Tanabe Wataru¹,Seo Kei¹,Yokoyama Rei¹,Ohkubo Jin¹,Ago Yukio¹⁴^ORCID,Hayashida Misuzu¹,Inoue Ken-ichi⁵⁶^ORCID,Takada Masahiko⁵^ORCID,Yamaguchi Shun⁷⁸,Nakazawa Takanobu¹⁹¹⁰^ORCID,Kaneko Shuji³^ORCID,Okuno Hiroyuki¹¹^ORCID,Yamanaka Akihiro¹²^ORCID,Hashimoto Hitoshi¹¹³¹⁴¹⁵¹⁶^ORCID

Affiliation:

1. Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan.

2. Institute for Transdisciplinary Graduate Degree Programs, Osaka University, Osaka, Japan.

3. Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.

4. Department of Cellular and Molecular Pharmacology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.

5. Systems Neuroscience Section, Primate Research Institute, Kyoto University, Aichi, Japan.

6. PRESTO, Japan Science and Technology Agency, Saitama, Japan.

7. Department of Morphological Neuroscience, Graduate School of Medicine, Gifu University, Gifu, Japan.

8. Center for Highly Advanced Integration of Nano and Life Sciences, Gifu University, Gifu, Japan.

9. Department of Pharmacology, Graduate School of Dentistry, Osaka University, Osaka, Japan.

10. Department of Bioscience, Tokyo University of Agriculture, Tokyo, Japan.

11. Laboratory of Biochemistry and Molecular Biology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.

12. Department of Neuroscience II, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan.

13. Molecular Research Center for Children’s Mental Development, United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University, and University of Fukui, Osaka Japan.

14. Division of Bioscience, Institute for Datability Science, Osaka University, Osaka, Japan.

15. Transdimensional Life Imaging Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Osaka, Japan.

16. Department of Molecular Pharmaceutical Sciences, Graduate School of Medicine, Osaka University, Osaka, Japan.

Abstract

The processing of stress responses involves brain-wide communication among cortical and subcortical regions; however, the underlying mechanisms remain elusive. Here, we show that the claustrum (CLA) is crucial for the control of stress-induced anxiety-related behaviors. A combined approach using brain activation mapping and machine learning showed that the CLA activation serves as a reliable marker of exposure to acute stressors. In TRAP2 mice, which allow activity-dependent genetic labeling, chemogenetic activation of the CLA neuronal ensemble tagged by acute social defeat stress (DS) elicited anxiety-related behaviors, whereas silencing of the CLA ensemble attenuated DS-induced anxiety-related behaviors. Moreover, the CLA received strong input from DS-activated basolateral amygdala neurons, and its circuit-selective optogenetic photostimulation temporarily elicited anxiety-related behaviors. Last, silencing of the CLA ensemble during stress exposure increased resistance to chronic DS. The CLA thus bidirectionally controls stress-induced emotional responses, and its inactivation can serve as a preventative strategy to increase stress resilience.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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