VGLL4 promotes osteoblast differentiation by antagonizing TEADs-inhibited Runx2 transcription-Reference-Cited by-同舟云学术

VGLL4 promotes osteoblast differentiation by antagonizing TEADs-inhibited Runx2 transcription

Published:2020-10-23 Issue:43 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Suo Jinlong¹^ORCID,Feng Xue¹^ORCID,Li Jiayi²,Wang Jinghui¹,Wang Zuoyun¹^ORCID,Zhang Lei¹³⁴^ORCID,Zou Weiguo¹³⁴^ORCID

Affiliation:

1. State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences; University of Chinese Academy of Sciences, Shanghai 200031, China.

2. Department of Laboratory Medicine, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai 201318, China.

3. School of Life Science and Technology, ShanghaiTech University, 100 Haike Road, Shanghai 201210, China.

4. Bio-Research Innovation Center, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Suzhou 215121, China.

Abstract

VGLL4 relieves TEADs-mediated RUNX2 transcriptional inhibition by impairing TEADs-RUNX2 interaction.

Funder

National Natural Science Foundation of China

Science and Technology Commission of Shanghai Municipality

National Key Research and Development Program of China Stem Cell and Translational Research

“Strategic Priority Research Program” of Chinese Academy of Sciences

Youth Innovation Promotion Association CAS

Shanghai Leading Talents Program

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference34 articles.

1. Correlation between genotype and supernumerary tooth formation in cleidocranial dysplasia

2. Mutations Involving the Transcription Factor CBFA1 Cause Cleidocranial Dysplasia

3. Targeted Disruption of Cbfa1 Results in a Complete Lack of Bone Formation owing to Maturational Arrest of Osteoblasts

4. Cbfa1, a Candidate Gene for Cleidocranial Dysplasia Syndrome, Is Essential for Osteoblast Differentiation and Bone Development

5. Osf2/Cbfa1: A Transcriptional Activator of Osteoblast Differentiation

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