Stable but not rigid: Chronic in vivo STED nanoscopy reveals extensive remodeling of spines, indicating multiple drivers of plasticity-Reference-Cited by-同舟云学术

Stable but not rigid: Chronic in vivo STED nanoscopy reveals extensive remodeling of spines, indicating multiple drivers of plasticity

Published:2021-06-11 Issue:24 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Steffens Heinz¹²^ORCID,Mott Alexander C.¹²^ORCID,Li Siyuan³⁴,Wegner Waja¹²,Švehla Pavel³⁴^ORCID,Kan Vanessa W. Y.³⁴,Wolf Fred²⁵,Liebscher Sabine³⁴⁶^ORCID,Willig Katrin I.¹²⁷^ORCID

Affiliation:

1. Optical Nanoscopy in Neuroscience, Center for Nanoscale Microscopy and Molecular Physiology of the Brain, University Medical Center Göttingen, Göttingen, Germany.

2. Max Planck Institute of Experimental Medicine, Göttingen, Germany.

3. Institute of Clinical Neuroimmunology, University Hospital, Ludwig-Maximilians-University Munich, Munich, Germany.

4. BioMedical Center, Faculty of Medicine, Ludwig-Maximilians-University Munich, Munich, Germany.

5. Max Planck Institute for Dynamics and Self-Organization; Campus Institute for Dynamics of Biological Networks, Göttingen, Germany.

6. Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.

7. Cluster of Excellence “Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells” (MBExC), University of Göttingen, Göttingen, Germany.

Abstract

STED microscopy uncovers a delicate balance of stability and volatility of stable spines in mouse cortex over 1 month.

Funder

Deutsche Forschungsgemeinschaft

DFG

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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