Sex-dependent fear memory impairment in cocaine-sired rat offspring

Author:

Rich Matthew T.1ORCID,Worobey Samantha J.1ORCID,Mankame Sharvari1ORCID,Pang Zhiping P.2ORCID,Swinford-Jackson Sarah E.1ORCID,Pierce R. Christopher1ORCID

Affiliation:

1. Brain Health Institute and Department of Psychiatry, Rutgers University, Piscataway, NJ 08854 USA.

2. Child Health Institute and Department of Neuroscience & Cell Biology, Rutgers University, New Brunswick, NJ 08901, USA.

Abstract

Cocaine self-administration by male rats results in neuronal and behavioral alterations in offspring, including responses to cocaine. Given the high degree of overlap between the brain systems underlying the pathological responses to cocaine and stress, we examined whether sire cocaine taking would influence fear-associated behavioral effects in drug-naïve adult male and female progeny. Sire cocaine exposure had no effect on contextual fear conditioning or its extinction in either male or female offspring. During cued fear conditioning, freezing behavior was enhanced in female, but not male, cocaine-sired progeny. In contrast, male cocaine-sired progeny exhibited enhanced expression of cue-conditioned fear during extinction. Long-term potentiation (LTP) was robust in the basolateral amygdala (BLA), which encodes fear conditioning, of female offspring but was completely absent in male offspring of cocaine-exposed sires. Collectively, these results indicate that cued fear memory is enhanced in the male progeny of cocaine exposed sires, which also have BLA synaptic plasticity deficits.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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