High-resolution cryo-EM structures of respiratory complex I: Mechanism, assembly, and disease-Reference-Cited by-同舟云学术

High-resolution cryo-EM structures of respiratory complex I: Mechanism, assembly, and disease

Published:2019-12-06 Issue:12 Volume:5 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Parey Kristian¹²³^ORCID,Haapanen Outi⁴^ORCID,Sharma Vivek⁴⁵^ORCID,Köfeler Harald⁶^ORCID,Züllig Thomas⁶^ORCID,Prinz Simone²^ORCID,Siegmund Karin¹³,Wittig Ilka⁷^ORCID,Mills Deryck J.²^ORCID,Vonck Janet²^ORCID,Kühlbrandt Werner²^ORCID,Zickermann Volker¹³^ORCID

Affiliation:

1. Institute of Biochemistry II, University Hospital, Goethe University, Frankfurt am Main, Germany.

2. Department of Structural Biology, Max Planck Institute of Biophysics, Frankfurt am Main, Germany.

3. Centre for Biomolecular Magnetic Resonance, Institute for Biophysical Chemistry, Goethe University, Frankfurt am Main, Germany.

4. Department of Physics, University of Helsinki, Helsinki, Finland.

5. Institute of Biotechnology, University of Helsinki, Helsinki, Finland.

6. Core Facility Mass Spectrometry, Medical University of Graz, Graz, Austria.

7. Functional Proteomics, SFB815 Core Unit, Medical School, Goethe University, Frankfurt am Main, Germany.

Abstract

Cryo-EM, yeast genetics, and simulations offer an integrated approach to assess structure, function, and assembly of complex I.

Funder

Deutsche Forschungsgemeinschaft

Academy of Finland

Sigrid Jusélius Foundation

Austrian Federal Ministry of Education

CHEMS doctoral school of the University of Helsinki

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference78 articles.

1. Mitochondrial Complex I

2. Mitochondrial complex I-linked disease

3. Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I

4. Slow active/inactive transition of the mitochondrial NADH-ubiquinone reductase

5. Mammalian Respiratory Complex I Through the Lens of Cryo-EM

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