Multiform antimicrobial resistance from a metabolic mutation

Author:

Schrader Sarah M.1ORCID,Botella Hélène12,Jansen Robert13ORCID,Ehrt Sabine1ORCID,Rhee Kyu1ORCID,Nathan Carl1ORCID,Vaubourgeix Julien12ORCID

Affiliation:

1. Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY, USA.

2. MRC Centre for Molecular Bacteriology and Infection, Imperial College London, London SW7 2AZ, UK.

3. Department of Microbiology, Radboud University, Nijmegen, Netherlands.

Abstract

Disruption of a metabolic pathway causes tolerance, high persistence, and MIC-shifted resistance to diverse antibiotics.

Funder

U.S. Department of Defense

National Institute of General Medical Sciences

National Institute of Allergy and Infectious Diseases

Potts Memorial Foundation

Department of Infectious Disease at Imperial College London

William Randolph Hearst Trust

Abby and Howard Milstein Program in Chemical Biology and Translational Medicine

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference81 articles.

1. Biology of antimicrobial resistance and approaches to combat it

2. J. O’Neill Review on AMR - Antimicrobial Resistance: Tackling a crisis for the health and wealth of nations (2014).

3. World Health Organization Global tuberculosis report 2019 (2019); http://apps.who.int/bookorders.

4. Epigenetic inheritance based evolution of antibiotic resistance in bacteria

5. A Novel Mechanism of Growth Phase-dependent Tolerance to Isoniazid in Mycobacteria

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