Characterizing smoking-induced transcriptional heterogeneity in the human bronchial epithelium at single-cell resolution

Author:

Duclos Grant E.1ORCID,Teixeira Vitor H.2ORCID,Autissier Patrick3ORCID,Gesthalter Yaron B.4,Reinders-Luinge Marjan A.5,Terrano Robert1,Dumas Yves M.1,Liu Gang1ORCID,Mazzilli Sarah A.1ORCID,Brandsma Corry-Anke5ORCID,van den Berge Maarten6,Janes Sam M.27ORCID,Timens Wim5ORCID,Lenburg Marc E.1,Spira Avrum18,Campbell Joshua D.1ORCID,Beane Jennifer1ORCID

Affiliation:

1. Department of Medicine, Boston University School of Medicine, Boston, MA, USA.

2. Lungs for Living Research Centre, UCL Respiratory, University College London, London, UK.

3. Boston University Flow Cytometry Core Facility, Boston University School of Medicine, Boston, MA, USA.

4. Department of Medicine, University of California San Francisco School of Medicine, San Francisco, CA, USA.

5. University of Groningen, University Medical Center Groningen, Department of Pathology and Medical Biology, Groningen, Netherlands.

6. University of Groningen, University Medical Center Groningen, Department of Pulmonary Diseases, Groningen, Netherlands.

7. Department of Thoracic Medicine, University College London Hospital, London, UK.

8. Johnson & Johnson Innovation, Cambridge, MA, USA.

Abstract

Single-cell RNA-Seq reveals smoking-induced bronchial cell type–specific alterations and a novel peri-goblet cell.

Funder

National Institutes of Health

U.S. Department of Defense

LUNGevity Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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