A GWAS in Latin Americans identifies novel face shape loci, implicating VPS13B and a Denisovan introgressed region in facial variation-Reference-Cited by-同舟云学术

A GWAS in Latin Americans identifies novel face shape loci, implicating VPS13B and a Denisovan introgressed region in facial variation

Published:2021-02-05 Issue:6 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Bonfante Betty¹^ORCID,Faux Pierre¹^ORCID,Navarro Nicolas²³^ORCID,Mendoza-Revilla Javier⁴⁵,Dubied Morgane²^ORCID,Montillot Charlotte⁶,Wentworth Emma⁷,Poloni Lauriane²³,Varón-González Ceferino⁸^ORCID,Jones Philip⁹,Xiong Ziyi¹⁰,Fuentes-Guajardo Macarena¹¹,Palmal Sagnik¹,Chacón-Duque Juan Camilo¹²,Hurtado Malena⁴,Villegas Valeria⁴,Granja Vanessa⁴,Jaramillo Claudia¹³,Arias William¹³,Barquera Rodrigo¹⁴¹⁵^ORCID,Everardo-Martínez Paola¹⁴,Sánchez-Quinto Mirsha¹⁶,Gómez-Valdés Jorge¹⁴,Villamil-Ramírez Hugo¹⁷,Silva de Cerqueira Caio C.¹⁸,Hünemeier Tábita¹⁹,Ramallo Virginia²⁰²¹,Liu Fan¹⁰²²²³^ORCID,Weinberg Seth M.²⁴²⁵²⁶^ORCID,Shaffer John R.²⁴²⁵,Stergiakouli Evie²⁷²⁸,Howe Laurence J.²⁷,Hysi Pirro G.²⁹^ORCID,Spector Timothy D.²⁹^ORCID,Gonzalez-José Rolando²¹,Schüler-Faccini Lavinia²⁰,Bortolini Maria-Cátira²⁰,Acuña-Alonzo Victor¹⁴,Canizales-Quinteros Samuel¹⁷,Gallo Carla⁴,Poletti Giovanni⁴,Bedoya Gabriel¹³,Rothhammer Francisco³⁰,Thauvin-Robinet Christel⁶³¹,Faivre Laurence⁶³¹,Costedoat Caroline¹,Balding David⁹³²,Cox Timothy³³,Kayser Manfred¹⁰,Duplomb Laurence⁶,Yalcin Binnaz⁶^ORCID,Cotney Justin⁷,Adhikari Kaustubh⁹³⁴^ORCID,Ruiz-Linares Andrés¹⁹³⁵^ORCID

Affiliation:

1. Aix-Marseille Université, CNRS, EFS, ADES, Marseille 13005, France.

2. Biogéosciences, UMR 6282 CNRS, EPHE, Université Bourgogne Franche-Comté, Dijon 21078, France.

3. EPHE, PSL University, Paris 75014, France.

4. Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, 31, Perú.

5. Unit of Human Evolutionary Genetics, Institut Pasteur, Paris 75015, France.

6. INSERM UMR 1231 Génétique des Anomalies du Développement, Université Bourgogne Franche-Comté, Dijon 21000, France.

7. Department of Genetics and Genome Sciences, University of Connecticut Health, Farmington, CT 06030, USA.

8. Institut de Systématique, Évolution, Biodiversité, ISYEB–UMR 7205–CNRS, MNHN, UPMC, EPHE, UA, Muséum National d’Histoire Naturelle, Sorbonne Universités, Paris 75005, France.

9. Department of Genetics, Evolution and Environment, and UCL Genetics Institute, University College London, London WC1E 6BT, UK.

10. Department of Genetic Identification, Erasmus MC University Medical Center Rotterdam, Rotterdam 3015GD, Netherlands.

11. Departamento de Tecnología Médica, Facultad de Ciencias de la Salud, Universidad de Tarapacá, Arica 1000000, Chile.

12. Division of Vertebrates and Anthropology, Department of Earth Sciences, Natural History Museum, London SW7 5BD, UK.

13. GENMOL (Genética Molecular), Universidad de Antioquia, Medellín 5001000, Colombia.

14. Molecular Genetics Laboratory, National School of Anthropology and History, Mexico City 14050, Mexico.

15. Department of Archaeogenetics, Max Planck Institute for the Science of Human History (MPI-SHH), Jena 07745, Germany.

16. Forensic Science, Faculty of Medicine, UNAM (Universidad Nacional Autónoma de México), Mexico City 06320, Mexico.

17. Unidad de Genomica de Poblaciones Aplicada a la Salud, Facultad de Química, UNAM-Instituto Nacional de Medicina Genómica, Mexico City 4510, Mexico.

18. Scientific Police of São Paulo State, Ourinhos-SP 19900-109, Brazil.

19. Departamento de Genética e Biologia Evolutiva, Instituto de Biociências, Universidade de São Paulo, São Paulo, SP 05508-090, Brazil.

20. Departamento de Genética, Universidade Federal do Rio Grande do Sul, Porto Alegre 90040-060, Brasil.

21. Instituto Patagónico de Ciencias Sociales y Humanas, Centro Nacional Patagónico, CONICET, Puerto Madryn U9129ACD, Argentina.

22. Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100864, China.

23. University of Chinese Academy of Sciences, Beijing 100864, China.

24. Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA 15260, USA.

25. Center for Craniofacial and Dental Genetics, Department of Oral Biology, University of Pittsburgh, Pittsburgh, PA 15260, USA.

26. Department of Anthropology, University of Pittsburgh, Pittsburgh, PA 15260, USA.

27. Medical Research Council Integrative Epidemiology Unit, Population Health Sciences, University of Bristol, Bristol BS1 2LY, UK.

28. School of Oral and Dental Sciences, University of Bristol, Bristol BS1 2LY, UK.

29. Department of Twin Research and Genetic Epidemiology, King’s College London, London WC2R 2LS, UK.

30. Instituto de Alta Investigación, Universidad de Tarapacá, Arica, Arica 1000000, Chile.

31. Centre de Référence Maladies Rares "Anomalies du Développement et Syndromes Malformatifs" de l’Est, Centre de Génétique, FHU TRANSLAD, CHU Dijon, Dijon 21000, France.

32. Melbourne Integrative Genomics, Schools of BioSciences and Mathematics & Statistics, University of Melbourne, Melbourne, VIC 3052, Australia.

33. Department of Oral and Craniofacial Sciences, School of Dentistry and Department of Pediatrics, School of Medicine, University of Missouri, Kansas City, MO 64108, USA.

34. School of Mathematics and Statistics, Faculty of Science, Technology, Engineering and Mathematics, The Open University, Milton Keynes MK7 6AA, UK.

35. Ministry of Education Key Laboratory of Contemporary Anthropology and Collaborative Innovation Center of Genetics and Development, School of Life Sciences and Human Phenome Institute, Fudan University, Yangpu District, Shanghai, China.

Abstract

We carried out a genome-wide association study in Latin Americans and identified novel face morphology loci..

Funder

National Institute of Dental and Craniofacial Research

Leverhulme Trust

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul

Universidad de Antioquia

BBSRC

Excellence Initiative of Aix-Marseille University - A*MIDEX

Fundação de Aperfeiçoamento de Pessoal de Nível Superior

Publisher