TET2 coactivates gene expression through demethylation of enhancers-Reference-Cited by-同舟云学术

TET2 coactivates gene expression through demethylation of enhancers

Published:2018-11-02 Issue:11 Volume:4 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Wang Lu¹²,Ozark Patrick A.¹²^ORCID,Smith Edwin R.¹²^ORCID,Zhao Zibo¹²,Marshall Stacy A.¹²^ORCID,Rendleman Emily J.¹²^ORCID,Piunti Andrea¹²^ORCID,Ryan Caila¹²,Whelan Anna L.¹²,Helmin Kathryn A.³,Morgan Marc Alard¹²^ORCID,Zou Lihua¹²^ORCID,Singer Benjamin D.¹²³^ORCID,Shilatifard Ali¹²^ORCID

Affiliation:

1. Simpson Querrey Center for Epigenetics, Northwestern University Feinberg School of Medicine, 320 East Superior Street, Chicago, IL 60611, USA.

2. Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

3. Division of Pulmonary and Critical Care, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

Abstract

An epigenetic axis directs a transcriptional program via enhancer activation by MLL3 COMPASS and TET2-dependent DNA demethylation.

Funder

National Institutes of Health

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference47 articles.

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4. Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

5. Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification

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