Deep tissue optical focusing and optogenetic modulation with time-reversed ultrasonically encoded light

Author:

Ruan Haowen1ORCID,Brake Joshua1ORCID,Robinson J. Elliott2ORCID,Liu Yan1ORCID,Jang Mooseok1,Xiao Cheng2,Zhou Chunyi2,Gradinaru Viviana2ORCID,Yang Changhuei1ORCID

Affiliation:

1. Department of Electrical Engineering, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA.

2. Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.

Abstract

Using ultrasound-guided optical wavefront shaping, the authors show enhanced optogenetic control in thick acute brain slices.

Funder

National Institutes of Health

Children’s Tumor Foundation

Heritage Medical Research Institute

GIST-Caltech Collaborative Research Program

Donna and Benjamin M. Rosen Bioengineering Center

Tianqiao and Chrissy Chen Institute for Neuroscience at Caltech

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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