Sexually divergent development of depression-related brain networks during healthy human adolescence-Reference-Cited by-同舟云学术

Sexually divergent development of depression-related brain networks during healthy human adolescence

Published:2022-05-27 Issue:21 Volume:8 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Dorfschmidt Lena¹^ORCID,Bethlehem Richard A.¹^ORCID,Seidlitz Jakob²³⁴^ORCID,Váša František⁵^ORCID,White Simon R.¹^ORCID,Romero-García Rafael¹^ORCID,Kitzbichler Manfred G.¹^ORCID,Aruldass Athina R.¹^ORCID,Morgan Sarah E.¹⁶⁷^ORCID,Goodyer Ian M.¹,Fonagy Peter⁸^ORCID,Jones Peter B.¹⁹^ORCID,Dolan Ray J.¹⁰¹¹^ORCID,Harrison Neil A.¹²¹³^ORCID,Vértes Petra E.¹^ORCID,Bullmore Edward T.¹^ORCID,

Affiliation:

1. Department of Psychiatry, University of Cambridge, Cambridge CB2 0SZ, UK.

2. Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA.

3. Department of Child and Adolescent Psychiatry and Behavioral Science, University of Pennsylvania, Philadelphia, PA 19104, USA.

4. Lifespan Brain Institute, Children’s Hospital of Philadelphia and Penn Medicine, Philadelphia, PA 19104, USA.

5. Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London SE5 8AF, UK.

6. The Alan Turing Institute, London NW1 2DB, UK.

7. Department of Computer Science and Technology, University of Cambridge, Cambridge CB2 0SZ, UK.

8. Research Department of Clinical, Educational and Health Psychology, University College London, London WC1E 6BT, UK.

9. Cambridgeshire and Peterborough NHS Foundation Trust, Huntingdon PE29 3RJ, UK.

10. Wellcome Trust Centre for Neuroimaging, University College London Queen Square Institute of Neurology.

11. Max Planck University College London Centre for Computational Psychiatry and Ageing Research, University College London, London WC1B 5EH, UK.

12. Department of Neuroscience, Brighton and Sussex Medical School, University of Sussex Campus, Brighton BN1 9RY, UK.

13. Cardiff University Brain Research Imaging Centre, Cardiff University, Cardiff CF24 4HQ, UK.

Abstract

Sexual differences in human brain development could be relevant to sex differences in the incidence of depression during adolescence. We tested for sex differences in parameters of normative brain network development using fMRI data on N = 298 healthy adolescents, aged 14 to 26 years, each scanned one to three times. Sexually divergent development of functional connectivity was located in the default mode network, limbic cortex, and subcortical nuclei. Females had a more “disruptive” pattern of development, where weak functional connectivity at age 14 became stronger during adolescence. This fMRI-derived map of sexually divergent brain network development was robustly colocated with i prior loci of reward-related brain activation ii a map of functional dysconnectivity in major depressive disorder (MDD), and iii an adult brain gene transcriptional pattern enriched for genes on the X chromosome, neurodevelopmental genes, and risk genes for MDD. We found normative sexual divergence in adolescent development of a cortico-subcortical brain functional network that is relevant to depression.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference103 articles.

1. Mapping changes in the human cortex throughout the span of life;Sowell E. R.;Neurosci.,2004

2. Structural Magnetic Resonance Imaging of the Adolescent Brain

3. Patterns of Coordinated Anatomical Change in Human Cortical Development: A Longitudinal Neuroimaging Study of Maturational Coupling

4. Adolescent Tuning of Association Cortex in Human Structural Brain Networks

5. Gene transcription profiles associated with inter-modular hubs and connection distance in human functional magnetic resonance imaging networks

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