Inhibition of protective immunity against Staphylococcus aureus infection by MHC-restricted immunodominance is overcome by vaccination-Reference-Cited by-同舟云学术

Inhibition of protective immunity against Staphylococcus aureus infection by MHC-restricted immunodominance is overcome by vaccination

Published:2020-04-03 Issue:14 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Si Youhui¹^ORCID,Zhao Fan¹,Beesetty Pavani²,Weiskopf Daniela³^ORCID,Li Zhaotao²,Tian Qiaomu¹^ORCID,Alegre Maria-Luisa⁴^ORCID,Sette Alessandro³⁵^ORCID,Chong Anita S.¹^ORCID,Montgomery Christopher P.²⁶^ORCID

Affiliation:

1. Department of Surgery, University of Chicago, Chicago, IL, USA.

2. Center for Microbial Pathogenesis, The Research Institute at Nationwide Children’s Hospital, Columbus, OH, USA.

3. Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA.

4. Department of Medicine, University of Chicago, Chicago, IL, USA.

5. Department of Medicine, University of California San Diego, La Jolla, CA, USA.

6. Department of Pediatrics, The Ohio State University, Columbus, OH, USA.

Abstract

MHC restriction determines whether S. aureus infection elicits protection, but vaccine efficacy is unconstrained by MHC haplotype.

Funder

National Institute of Allergy and Infectious Diseases

National Institute of Arthritis and Musculoskeletal and Skin Diseases

Immune Epitope Database and Analysis Program

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference43 articles.

1. Community-Associated Methicillin-Resistant Staphylococcus aureus : Epidemiology and Clinical Consequences of an Emerging Epidemic

2. Community-Acquired Methicillin-Resistant Staphylococcus aureus in Children With No Identified Predisposing Risk

3. Staphylococcus aureus Skin Infection Recurrences Among Household Members: An Examination of Host, Behavioral, and Pathogen-Level Predictors

4. A Serologic Correlate of Protective Immunity Against Community-Onset Staphylococcus aureus Infection

5. High Staphylococcus aureus Colonization Prevalence among Patients with Skin and Soft Tissue Infections and Controls in an Urban Emergency Department

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